• Vaccine Name: cAdVaxM(fus)
• Target Pathogen: Marburg Virus
• Target Disease: Hemorrhagic fever
• Vaccine Ontology ID: VO_0004646
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• GP from Musoke Marburgvirus gene engineering:
  • Type: Recombinant vector construction
  • Description: Novel gene-based vaccine candidates which express the viral glycoprotein (GP) from either the Ci67, Ravn or Musoke strain of MARV (Wang et al., 2006).
  • Detailed Gene Information: Click Here.
• GP from Marburg virus Ravn gene engineering:
  • Type: Recombinant vector construction
  • Description: Novel gene-based vaccine candidates which express the viral glycoprotein (GP) from either the Ci67, Ravn or Musoke strain of MARV (Wang et al., 2006).
  • Detailed Gene Information: Click Here.
• GP from Marburg virus Ci67 gene engineering:
  • Type: Recombinant vector construction
  • Description: Novel gene-based vaccine candidates which express the viral glycoprotein (GP) from either the Ci67, Ravn or Musoke strain of MARV (Wang et al., 2006).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001086
• Preparation: Three novel gene-based vaccine candidates which express the viral glycoprotein (GP) from either the Ci67, Ravn or Musoke strain of MARV (Wang et al., 2006).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Immunization of mice with complex adenovirus (Ad)-based vaccine candidates (cAdVax vaccines) (Wang et al., 2006).
• Vaccine Immune Response Type: VO_0003057
• Description: Vaccination led to efficient production of both antibodies and cytotoxic T lymphocytes (CTL) specific to Musoke strain GP and Ci67 strain GP, respectively. Antibody responses were also shown to be cross-reactive across the MARV strains, but not cross-reactive to Ebola virus, a related filovirus. Additionally, three 1 x 10(8)pfu doses of vaccine vector were demonstrated to be safe in mice, as this did not lead to any detectable toxicity in liver or spleen (Wang et al., 2006).