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complex adenovirus vaccine vector |
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Vaxvec ID |
36 |
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Vaccine Vector Name |
complex adenovirus vaccine vector |
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Alternative Names |
CAdVax vaccine vector |
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Vector VO ID |
VO_0001086
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Advantage |
CAdVax vectors are capable of carrying large transgene inserts of up to 7 kilobases or six different genes. This property depends on each gene's size. The CAdVax platform allows for multiantigen expression from each vector, which lessens the total number of components required for a panfilovirus vaccine (Swenson et al., 2008). |
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Safety |
When vaccinating nonhuman primates, 100% protection was exhibited against infection by two species of Ebola virus and three Marburg virus subtypes, each of which was administered at 1,000 times the lethal dose (Swenson et al., 2008). |
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Description |
A study contributed strong proof of concept for a single vaccine against many filoviruses using the CAdVax platform (Swenson et al., 2008). When vaccinating nonhuman primates, 100% protection was exhibited against infection by two species of Ebola virus and three Marburg virus subtypes, each of which was administered at 1,000 times the lethal dose (Swenson et al., 2008). |
| Related Vaccine(s) |
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| References |
Holman et al., 2009: Holman DH, Penn-Nicholson A, Wang D, Woraratanadharm J, Harr MK, Luo M, Maher EM, Holbrook MR, Dong JY. A complex adenovirus-vectored vaccine against Rift Valley fever virus protects mice against lethal infection in the presence of preexisting vector immunity. Clinical and vaccine immunology : CVI. 2009; 16(11); 1624-1632. [PubMed: 19776190].
Raviprakash et al., 2008: Raviprakash K, Wang D, Ewing D, Holman DH, Block K, Woraratanadharm J, Chen L, Hayes C, Dong JY, Porter K. A tetravalent dengue vaccine based on a complex adenovirus vector provides significant protection in rhesus monkeys against all four serotypes of dengue virus. Journal of virology. 2008; 82(14); 6927-6934. [PubMed: 18480438].
Schepp-Berglind et al., 2007: Schepp-Berglind J, Luo M, Wang D, Wicker JA, Raja NU, Hoel BD, Holman DH, Barrett AD, Dong JY. Complex adenovirus-mediated expression of West Nile virus C, PreM, E, and NS1 proteins induces both humoral and cellular immune responses. Clinical and vaccine immunology : CVI. 2007; 14(9); 1117-1126. [PubMed: 17634508].
Swenson et al., 2008: Swenson DL, Wang D, Luo M, Warfield KL, Woraratanadharm J, Holman DH, Dong JY, Pratt WD. Vaccine to confer to nonhuman primates complete protection against multistrain Ebola and Marburg virus infections. Clinical and vaccine immunology : CVI. 2008; 15(3); 460-467. [PubMed: 18216185].
Wang et al., 2006: Wang D, Raja NU, Trubey CM, Juompan LY, Luo M, Woraratanadharm J, Deitz SB, Yu H, Swain BM, Moore KM, Pratt WD, Hart MK, Dong JY. Development of a cAdVax-based bivalent ebola virus vaccine that induces immune responses against both the Sudan and Zaire species of Ebola virus. Journal of virology. 2006; 80(6); 2738-2746. [PubMed: 16501083].
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