VIOLIN: Vaccine Investigation and Online Information Network

E6 Type 16
Gene Name	E6 Type 16
Sequence Strain (Species/Organism)	Human papillomavirus type 16
VO ID	VO_0011107
NCBI Gene ID	1489078
NCBI Protein GI	9627104
Locus Tag	HpV16gp1
Genbank Accession	AB663688
Protein Accession	NP_041325
Taxonomy ID	333760
Gene Starting Position	7124
Gene Ending Position	7600
Gene Strand (Orientation)	+
Protein Name	transforming protein E6
Protein pI	8.97
Protein Weight	18789.29
Protein Length	158
Protein Note	E6 ORF from 65 to 559; putative
DNA Sequence	>NC_001526.4:7124-7600 Human papillomavirus type 16, complete genome TATGCACCAAAAGAGAACTGCAATGTTTCAGGACCCACAGGAGCGACCCAGAAAGTTACCACAGTTATGC ACAGAGCTGCAAACAACTATACATGATATAATATTAGAATGTGTGTACTGCAAGCAACAGTTACTGCGAC GTGAGGTATATGACTTTGCTTTTCGGGATTTATGCATAGTATATAGAGATGGGAATCCATATGCTGTATG TGATAAATGTTTAAAGTTTTATTCTAAAATTAGTGAGTATAGACATTATTGTTATAGTTTGTATGGAACA ACATTAGAACAGCAATACAACAAACCGTTGTGTGATTTGTTAATTAGGTGTATTAACTGTCAAAAGCCAC TGTGTCCTGAAGAAAAGCAAAGACATCTGGACAAAAAGCAAAGATTCCATAATATAAGGGGTCGGTGGAC CGGTCGATGTATGTCTTGTTGCAGATCATCAAGAACACGTAGAGAAACCCAGCTGTA
Protein Sequence	>NP_041325.1 transforming protein E6 [Human papillomavirus type 16] MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVC DKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWT GRCMSCCRSSRTRRETQL
Molecule Role	Protective antigen
Molecule Role Annotation	C57BL/6 mice vaccinated with pNGVL4a-E6/opt are able to generate potent protective and therapeutic antitumor effects against challenge with E6-expressing tumor cell line, TC-1 of HPV (Lin et al., 2006).
Related Vaccines(s)	Human papillomavirus DNA vaccine CRT/E7 DNA , Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2 , Human papillomavirus DNA vaccine pNGVL4a-E6/opt
References

E6 Type 16