• Vaccine Name: VEE virus DNA vaccine VEEV IA/B parent encoding structural genes
• Target Pathogen: VEE Virus
• Target Disease: Venezuelan equine encephalitis
• Vaccine Ontology ID: VO_0004421
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: VEEV subtype IA/B capsid protein (C) and envelope glycoproteins (E1 and E2) (Dupuy et al., 2009)
• E1 glycoprotein gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• E2 envelope protein gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid: pES DNA vaccine plasmid
  • DNA vaccine plasmid name: pES DNA vaccine plasmid
  • DNA vaccine plasmid VO ID: VO_0000254
• Immunization Route: Intradermal injection (i.d.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The vaccine was able to induce increased total anti-VEEV IA/B antibody responses and increased neutralizing antibody responses (Dupuy et al., 2009).
• Efficacy: The VEEV IA/B parent construct protected 80% of the mice from the lethal challenge, which is the same level of protection elicited by this DNA vaccine in a previous study. As in the previous study, mice vaccinated with the VEEV IA/B parent displayed signs of illness after challenge including ruffled fur, loss of appetite, and inactivity; however, the surviving mice completely recovered before the end of the 28 day post-challenge observation period (Dupuy et al., 2009).