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E2 envelope protein
Gene Name	E2 envelope protein
Sequence Strain (Species/Organism)	Venezuelan equine encephalitis virus
VO ID	VO_0011265
NCBI Protein GI	25140296
Other Database IDs	CDD:279311
Taxonomy ID	11036
Protein Name	E2 envelope protein
Protein pI	8.59
Protein Weight	44311.99
Protein Length	503
Protein Note	putative
Protein Sequence	>NP_741966.1 E2 envelope protein [Venezuelan equine encephalitis virus] STEELFKEYKLTRPYMARCIRCAVGSCHSPIAIEAVKSDGHDGYVRLQTSSQYGLDSSGNLKGRTMRYDM HGTIEEIPLHQVSLHTSRPCHIVDGHGYFLLARCPAGDSITMEFKKGSVTHSCSVPYEVKFNPVGRELYT HPPEHGAEQACQVYAHDAQNRGAYVEMHLPGSEVDSSLISLSGSSVTVTPPVGTSALVKCKCGGTKISET INKAKQFSQCTKKEQCRAYRLQNDKWVYNSDKLPKAAGATLKGKLHVPFLLADGKCTVPLAPEPMITFGF RSVSLKLHPKNPTYLTTRQLADEPHYTHELISEPAVRNFTVTEKGWEFVWGNHPPKRFWAQETAPGNPHG LPHEVITHYYHRYPMSTILGLSICAAIVTVSVAASTWLFCKSRVSCLTPYRLTPNARMPLCLAVLCCART ARA
Molecule Role	Protective antigen
Molecule Role Annotation	Since the E2 amino-terminal sequence for all VEE subtype viruses is conserved, we tested the protective capacity in mice of passively transferred mAb 1A2B-10 and found it to protect from both epizootic and enzootic VEE virus challenge. Since horses are an important natural host for VEE virus, pep1-19 was used to immunize horses and was found to be immunogenic and to elicit virus-reactive antibody (Hunt and Roehrig, 1995).
Related Vaccines(s)	VEE virus DNA vaccine VEEV IA/B parent encoding structural genes
References