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E1 glycoprotein

Gene Name E1 glycoprotein
Sequence Strain (Species/Organism) Venezuelan equine encephalitis virus
VO ID VO_0011267
NCBI Protein GI 798795
Other Database IDs CDD:201874
Taxonomy ID 11036
Protein Name E1 glycoprotein
Protein pI 7.54
Protein Weight 3856.25
Protein Length 114
Protein Note Alphavirus E1 glycoprotein; pfam01589
Protein Sequence
>AAA65907.1 E1 glycoprotein, partial [Venezuelan equine encephalitis virus]
WTWLTSLLGGSAVIIIIGLVLATIVAMYVLTNQKHN

Molecule Role Protective antigen
Molecule Role Annotation The monoclonal antibody against E1 glycoprotein protect outbred albino mice from lethal infection caused by the virulent strain Trd of the VEE virus (Agapov et al., 1994).
Additional Molecule Role Virmugen
Additional Molecule Role Annotation A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice and provides complete protection against challenge with wild type VEE (Davis et al., 1995).
Related Vaccines(s) VEE virus DNA vaccine VEEV IA/B parent encoding structural genes , VEE Virus PE2/E1 mutant vaccine
References