• Vaccine Name: Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
• Target Pathogen: Salmonella spp.
• Target Disease: Salmonellosis
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Pigs
• cpxA gene engineering:
  • Type: Gene mutation
  • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
  • Detailed Gene Information: Click Here.
• gyrA gene engineering:
  • Type: Gene mutation
  • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
  • Detailed Gene Information: Click Here.
• rpoB gene engineering:
  • Type: Gene mutation
  • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
  • Detailed Gene Information: Click Here.
• Immunization Route: Oral immunization

Pig Response

• Persistence: A gyrA/cpxA/rpoB mutant was attenuated in pigs (Roesler et al., 2004).
• Efficacy: A gyrA/cpxA/rpoB mutant protected pigs against challenge with wild type Salmonella Typhimurium (Roesler et al., 2004).
• Host IgM response
  • Description: A significant discrimination between vaccinated and non-vaccinated pigs was observed when IgM was measured after challenge, but here, the non-immunized animals had an elevated humoral antibody response after challenge with wild type Salmonella. The first significant difference was seen on day 35 after vaccination (Roesler et al., 2004).
  • Detailed Gene Information: Click Here.