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rpoB
Gene Name	rpoB
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID	1255679
NCBI Protein GI	16767407
Locus Tag	STM4153
Genbank Accession	AF170176
Protein Accession	NP_463022
Taxonomy ID	700720
Gene Starting Position	4365907
Gene Ending Position	4369935
Gene Strand (Orientation)	+
Protein Name	DNA-directed RNA polymerase subunit beta
Protein pI	4.89
Protein Weight	139687.68
Protein Length	1342
Protein Note	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
DNA Sequence	>gi\|16763390:4365907-4369935 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome TATGGTTTACTCCTATACCGAGAAAAAACGTATTCGTAAGGATTTTGGTAAACGTCCACAAGTTCTGGAT GTACCTTATCTCCTTTCTATCCAGCTTGACTCGTTTCAGAAGTTTATCGAGCAAGATCCTGAAGGGCAGT ACGGCCTGGAAGCAGCCTTCCGTTCCGTGTTCCCGATTCAGAGCTACAGCGGTAATTCCGAGCTGCAGTA CGTCAGCTACCGCCTTGGCGAACCGGTGTTTGACGTTCAGGAATGTCAGATCCGTGGCGTGACCTATTCC GCACCGCTGCGCGTAAAACTGCGTCTGGTGATCTACGAGCGCGAAGCGCCGGAAGGCACCGTAAAAGACA TTAAAGAACAAGAAGTCTACATGGGCGAAATTCCGCTCATGACCGACAACGGTACCTTTGTTATCAACGG TACTGAGCGTGTTATCGTTTCTCAGCTGCACCGTAGCCCTGGCGTCTTCTTTGACTCCGACAAAGGTAAA ACCCACTCTTCGGGTAAAGTGCTGTATAACGCGCGCATCATTCCTTACCGTGGTTCCTGGCTGGACTTCG AATTCGATCCGAAGGACAACCTGTTCGTACGTATCGACCGTCGCCGTAAACTACCTGCGACCATCATCCT GCGTGCGCTGAACTACACCACTGAGCAGATCCTTGACCTGTTCTTTGAGAAAGTCGTCTTCGAAATTCGC GACAACAAACTGCAGATGGAGCTGATTCCAGAACGTCTGCGTGGCGAAACCGCGTCGTTCGATATCGAAG CTAACGGCAAAGTGTACGTTGAAAAAGGCCGTCGCATTACCGCGCGTCACATCCGTCAGCTGGAAAAAGA CGATATCAAGCATATCGAAGTTCCGGTTGAGTACATCGCAGGTAAAGTCGTCTCTAAAGACTACGTTGAC GAATCTACTGGCGAGCTGATCTGCGCGGCGAACATGGAGCTGAGCCTGGATCTGCTGGCTAAGCTGAGCC AGTCCGGCCACAAGCGTATCGAAACGCTGTTTACCAACGATCTGGACCACGGCCCGTACATTTCTGAAAC GGTACGCGTCGACCCAACTAACGATCGTCTGAGCGCGCTGGTAGAAATCTACCGCATGATGCGCCCTGGT GAGCCGCCGACACGCGAAGCGGCTGAAAGCCTGTTTGAGAACCTGTTCTTCTCCGAAGACCGCTATGACC TGTCTGCGGTGGGTCGTATGAAGTTCAACCGTTCTCTGCTGCGCGACGAAATCGAAGGTTCCGGTATCCT GAGCAAAGACGACATCATTGATGTCATGAAGAAGCTCATCGATATCCGTAACGGTAAAGGCGAAGTGGAT GATATCGACCACCTCGGCAACCGTCGTATCCGTTCCGTCGGCGAAATGGCGGAAAACCAGTTCCGCGTTG GCCTGGTGCGTGTAGAGCGTGCGGTGAAAGAGCGTCTGTCTCTGGGCGATCTGGATACCCTGATGCCTCA GGATATGATCAACGCCAAGCCGATTTCCGCCGCAGTGAAAGAGTTCTTTGGTTCCAGCCAGCTGTCTCAG TTTATGGACCAGAACAACCCGCTGTCTGAGATTACGCACAAACGTCGTATCTCCGCACTCGGCCCAGGCG GTCTGACCCGCGAACGCGCAGGCTTCGAAGTTCGAGACGTACACCCGACGCACTACGGTCGCGTATGTCC TATCGAAACGCCGGAAGGTCCGAACATCGGTCTGATCAACTCCCTGTCCGTGTACGCACAGACTAACGAA TATGGCTTCCTTGAGACGCCGTACCGTCGTGTGGTTGATGGCGTGGTTACTGACGAAATTCATTACCTGT CTGCTATCGAAGAAGGCAACTACGTTATCGCTCAGGCGAACTCCAACCTGGATGACGAAGGCCACTTTGT AGAAGATTTGGTGACCTGCCGTAGCAAAGGCGAATCCAGCTTGTTCAGCCGCGACCAGGTTGACTACATG GACGTTTCCACCCAGCAGGTGGTCTCCGTCGGTGCGTCCCTGATCCCGTTCCTGGAACACGATGACGCCA ACCGTGCATTGATGGGTGCGAACATGCAACGTCAGGCGGTTCCGACTCTGCGCGCTGACAAGCCGCTGGT GGGTACCGGTATGGAACGTGCTGTCGCCGTCGACTCCGGTGTTACTGCAGTAGCTAAACGTGGCGGTACT GTTCAGTACGTGGATGCGTCCCGTATCGTTATCAAAGTTAACGAAGACGAGATGTACCCGGGCGAAGCGG GTATCGACATCTATAACCTGACCAAATACACCCGCTCTAACCAGAACACCTGTATCAACCAGATGCCATG TGTGTCTCTGGGCGAGCCGGTTGAACGCGGCGACGTGCTGGCAGACGGTCCGTCCACCGACCTCGGTGAA CTGGCGCTCGGTCAGAACATGCGCGTGGCGTTCATGCCGTGGAACGGCTACAACTTCGAAGACTCCATTC TCGTTTCCGAGCGTGTTGTCCAGGAAGACCGTTTCACCACCATCCACATTCAGGAACTGGCGTGCGTGTC CCGTGACACCAAGCTGGGGCCGGAAGAGATCACCGCTGATATCCCGAACGTGGGTGAAGCTGCGCTCTCC AAACTGGATGAATCCGGTATCGTTTACATCGGCGCGGAAGTGACAGGCGGTGACATTCTGGTCGGTAAGG TGACGCCGAAAGGTGAAACCCAGCTGACGCCGGAAGAGAAACTGCTGCGTGCGATCTTCGGTGAGAAAGC GTCTGACGTTAAAGACTCTTCTCTGCGCGTACCTAACGGTGTCTCCGGTACGGTTATCGACGTTCAGGTC TTTACTCGCGATGGCGTAGAAAAAGACAAACGTGCTCTGGAAATCGAAGAGATGCAGCTCAAGCAGGCGA AAAAAGACCTGTCTGAAGAACTGCAGATCCTCGAAGCGGGCCTGTTTAGCCGTATCCGTGCGGTGCTGGT TTCCAGCGGCGTTGAAGCTGAGAAGCTCGACAAACTGCCGCGCGACCGCTGGCTGGAACTCGGTCTGACC GACGAAGAGAAACAAAATCAGCTGGAACAACTGGCTGAGCAGTATGACGAACTGAAACACGAGTTCGAGA AAAAACTTGAAGCGAAGCGCCGTAAAATCACCCAGGGCGACGATCTGGCGCCGGGCGTGCTGAAGATCGT GAAGGTCTATCTGGCCGTTAAACGCCGTATCCAGCCGGGTGATAAGATGGCAGGTCGTCACGGTAACAAG GGTGTTATCTCTAAGATCAACCCGATCGAAGACATGCCTTACGATGAAAACGGCACGCCGGTAGACATCG TACTGAACCCGCTGGGCGTACCGTCTCGTATGAACATCGGCCAGATTCTGGAAACCCACCTGGGTATGGC TGCGAAAGGTATTGGCGACAAGATTAACGCCATGCTGAAACAGCAGCAGGAAGTCGCGAAACTGCGCGAA TTCATCCAGCGTGCCTACGATCTGGGCGCCGACGTTCGTCAGAAAGTCGACCTGAGCACCTTCAGCGATG ATGAAGTGCTGCGTCTGGCAGAAAACCTGCGCAAAGGTATGCCGATTGCCACACCAGTGTTTGACGGTGC GAAAGAAGCGGAAATCAAAGAGCTGCTGAAACTGGGCGACCTGCCGACCTCCGGTCAGATCACCCTGTTC GATGGCCGTACGGGTGAACAGTTCGAACGTCCGGTAACCGTCGGTTACATGTACATGCTGAAACTGAACC ACCTGGTTGATGACAAGATGCATGCGCGTTCTACCGGTTCTTACAGCCTGGTTACTCAGCAGCCGCTGGG TGGTAAGGCGCAGTTCGGTGGTCAGCGCTTCGGGGAGATGGAAGTGTGGGCGCTGGAAGCTTACGGCGCC GCCTACACCCTGCAGGAAATGCTCACCGTTAAGTCTGATGACGTGAATGGTCGTACCAAGATGTATAAGA ACATCGTGGACGGCAACCATCAGATGGAACCGGGTATGCCGGAATCCTTCAACGTTCTGTTGAAAGAGAT CCGCTCGCTGGGCATCAACATCGAACTGGAAGACGAGTA
Protein Sequence	>gi\|16767407\|ref\|NP_463022.1\| DNA-directed RNA polymerase subunit beta [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQY VSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVING TERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIIL RALNYTTEQILDLFFEKVVFEIRDNKLQMELIPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKD DIKHIEVPVEYIAGKVVSKDYVDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISET VRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLRDEIEGSGIL SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQ DMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCP IETPEGPNIGLINSLSVYAQTNEYGFLETPYRRVVDGVVTDEIHYLSAIEEGNYVIAQANSNLDDEGHFV EDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLV GTGMERAVAVDSGVTAVAKRGGTVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPC VSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKA SDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLV SSGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIV KVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMA AKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDDEVLRLAENLRKGMPIATPVFDGA KEAEIKELLKLGDLPTSGQITLFDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEI RSLGINIELEDE
Molecule Role	Virmugen
Molecule Role Annotation	A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs (Roesler et al., 2004).
Related Vaccines(s)	Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
References

rpoB