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cpxA

Gene Name cpxA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1255585
NCBI Protein GI 16767324
Locus Tag STM4058
Genbank Accession AE006468
Protein Accession NP_462939
Taxonomy ID 700720
Gene Starting Position 4268375
Gene Ending Position 4269748
Gene Strand (Orientation) -
Protein Name two-component sensor protein
Protein pI 5.57
Protein Weight 49326.93
Protein Length 457
Protein Note part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
DNA Sequence 
>gi|16763390:4268375-4269748 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
TTTAGGTTCGCTTGTACAGCGGTAGCCACAGCGTAAGCCGCAACCCACCCAGCGGGCTATCGTCAGCCTT
CACCCAGCCGCGGTGCTGCTGCATGGCGCTTTCGACAATCGCCAGCCCCAGCCCGGTGCCGCCAGACTCG
CGGTCGCGCGCCTCATCAGTGCGATAGAACGGACGGAAGATCTGCTCGCGGTCTTCAGGGCTGACGCCCG
GCCCGTCGTCATCGACCGTGATCGTAATACCGTCTTTATCCACCGAGAAGCCGACTTCAATCTTCGTATG
TGAATAGCGCAGCGCATTACGAACTATATTTTCCAGCGCGCTTTCCAGCGCGTTTGGGTTGCCATAGAGC
GGCCACGGCCCCGGCGGATAATTTACCGTTAACGACTTGCCCATCTGTTCGGCTTCAAAGGCGGCGTTAT
CCAGCACTTCGCCCCATAGCTGATTGGCTTTCATCGTTTCGCTGACCAGCGCATTTTTCTGTTGGTTACG
CGACATCACCAGCAGGTCATTGATCATGCTGTCCAGACGCTGCGCTTCGGTTTCAATACGCTCCAGCTCT
TTGCTTTCGCCGCCACGACGACGCAGCAGCGCGGTACCCAGTTGCAGGCGCGTAAGGGGCGTTCGTAGCT
CATGGGAGATGTCTGACAGCAAACGCTGCTGCGAGGTCATCATCCGTTCCAGCGCCGTCACCATCTGGTT
AAAACTGGCGCCAGCGGCGAGGAACTCCTGCGGACCCGCCTCCAGCTCCGGATGCTGACGCAGGTTGCCT
TGCGCCACTTCATCAGCCGCGTTTTTCAACTTACGCGCCGGTTTCGCCAGACTCCATGCCAGCCATAGCA
AGAGCGGCGAACTGACCAGCATCGTGACAATGAGCAACAGAAGCGGGCGGTCAAACAGCAGATTAATAAA
ATCGGATTGCGAACTGCTGGCCGGTCGAATCAAGTAAAGCTGGTAATTATCCTCTCCGTCGCGAACGGAG
AACGGCCCCACCATCTCTACGCGGCCATATTTTTTCTTCTGCGGATGATCGGCGTTATCCGCCTGACCAA
TGAAGTTACGAATGATCTGCATTTCGCTGCGTTCAGCGCCGATCACGCGTCCTTCAGAGGTCACCAGTAA
TAACCGCTGTCCAGGCGGCGCCCACTTATCGATCGCGCGGAACAGGCGACGCCACCACATCAGGTCGTTG
GGCGGATCGTTCGCAAGTTCAGCTTCTACATGTTGCTCTATCATCAATCCCTGGCGCTGTTCGCTGTCCA
GCAGCTCGGTCATCTGGCGTGAATCGAGCTTGGGCAACATCAGGACCAGCATTAGCACCAGCGCCAGCGT
CAACCAGAAGATGGCGAAGATGCGCGCGGTTAAACTTCCTATCA
Protein Sequence 
>gi|16767324|ref|NP_462939.1| two-component sensor protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRR
LFRAIDKWAPPGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVEMVGPFSVRDGEDN
YQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSSPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPE
LEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETE
AQRLDSMINDLLVMSRNQQKNALVSETMKANQLWGEVLDNAAFEAEQMGKSLTVNYPPGPWPLYGNPNAL
ESALENIVRNALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
LAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT
Molecule Role Virmugen
Molecule Role Annotation A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated and protected against challenge in pigs (Roesler et al., 2004).
Related Vaccines(s) Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
References