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Vaccine Detail
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VEE Virus PE2/E1 mutant vaccine |
| Vaccine Information |
- Vaccine Name: VEE Virus PE2/E1 mutant vaccine
- Target Pathogen: VEE Virus
- Target Disease: Venezuelan equine encephalitis
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E1 glycoprotein
gene engineering:
- Type: Gene mutation
- Description: This PE2/E1 mutant is from Venezuelan equine encephalitis virus (Davis et al., 1995).
- Detailed Gene Information: Click Here.
- PE2
gene engineering:
- Type: Gene mutation
- Description: This PE2/E1 mutant is from Venezuelan equine encephalitis virus (Davis et al., 1995).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Persistence: A PE2/E1 mutant is highly attenuated in mice (Davis et al., 1995).
- Efficacy: A PE2/E1 mutant induces complete protection in mice from challenge with wild type VEE virus (Davis et al., 1995).
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| References |
Davis et al., 1995: Davis NL, Brown KW, Greenwald GF, Zajac AJ, Zacny VL, Smith JF, Johnston RE. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology. 1995; 212(1); 102-110. [PubMed: 7676619].
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