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CTLA4
Gene Name	CTLA4
Sequence Strain (Species/Organism)	Homo sapiens
NCBI Gene ID	1493
NCBI Protein GI	83700231
Genbank Accession	AC010138
Protein Accession	NP_001032720
3D structure: PDB ID	1AH1
Taxonomy ID	9606
Chromosome No	2
Gene Starting Position	203867787
Gene Ending Position	203873959
Gene Strand (Orientation)	+
Protein Name	transcript variant 1
Protein pI	8.56
Protein Weight	17855.22
Protein Length	174
Protein Note	Also known as CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
DNA Sequence	>NC_000002.12:203867787-203873959 Homo sapiens chromosome 2, GRCh38.p12 Primary Assembly CCTTCTGTGTGTGCACATGTGTAATACATATCTGGGATCAAAGCTATCTATATAAAGTCCTTGATTCTGT GTGGGTTCAAACACATTTCAAAGCTTCAGGATCCTGAAAGGTTTTGCTCTACTTCCTGAAGACCTGAACA CCGCTCCCATAAAGCCATGGCTTGCCTTGGATTTCAGCGGCACAAGGCTCAGCTGAACCTGGCTACCAGG ACCTGGCCCTGCACTCTCCTGTTTTTTCTTCTCTTCATCCCTGTCTTCTGCAAAGGTGAGTGAGACTTTT GGAGCATGAAGATGGAGGAGGTGTTTCTCCTACCTGGGTTTCATTTGTTTCAGCAGTCAAAGGCAGTGAT TTATAGCAAAGCCAGAAGTTAAAGGTAAAACTCCAATCTGGCTTGGCTGGCTCTGTATTCCAGGGCCAGC AGGGAGCAGTTGGGCGGCAGCAAATAAGGCAAAGAGATAGCTCAGAACAGAGCGCCAGGTATTTAGTAGG GGCTTCATGAATGCATGTGAGTTGGTTTAGTAGAGAGACACAGGCAATTTCAGACCCTTCTATGAGACTG GAAGTGATTTAAGAGGGAAAGGATAGCCATAGTCCTGAATACATTTGAGCTGGGTTTCAGGATGAGCTCA CAAGTTCCTTTAAAAAAAATTGACTTAAGCAAATCCTGGGAAGAGTTTTTTTGCTATACAATTCAAGGTT TTAAGGTCCTCGGATTCATATACTTTATAAATGAATTAGCCAGCTTGTTTAAAATGTAGGGAAATTGTGG GAAGAATGCCTTCTTTACTTAATTCAAGGTTTTAAGGTTCTCTTAATCAATTCTACTAGCTAATTAGCCA ATTATTTAAAAATAAAAGTTTGAAATTGCCAAAAAAAAAAGACAAGGAAAAGGAAAGAAAGAAAGCCACC AGTCTGTTTGGCATACAATACTTAATTGTTGCCTGACCTACGTGTGGGTTTCAGATGCAGATCCTCAGTT TTCAGCTCTTCAGAGACTGACACCAGGTTTGTTACACGGCTTAAAATGATGAGTATATCCATTGAATCTC AACCTTATCTCTCTCTAGACCTTCTTGGTTAAGAAACCATGTAGTTTGTATGAAGTAGGTACTCAAAAGA TATTTGATGATTTAATTTTTACTGGAGAAGAAATATTCATATATGTTTTCTTATTTTTACATGTTTTAAA TATGTAAAGATTAAATAAACACTCTTAGAAGTATTTAAATTTCCTAAAGTAAATTTATCTCAACCAGTAA CAGGACCCTCCCAATACTGGAAAGTTGAGTGTGACCGCATTTAGTGGTGATGAGTGTGAGCTTGCTTGGG GAGAGGGCAGGACATTTAGGATTTCTTAAGCTTAGAGTCAATACAATAAAGATTATTGAGTGCTCACTTG GGTGGGCTATAATCACTGCTCACAGGAGTTCATGAACCACAAGTAAAAGAGTGAGGAGATATGATTAGCT CACAAATAACTTTAATACAGAGCAGAAAGTAATGAACTACTGCAATGGAGTTATCACAGTGCTAAGGATG CTCAGAGGGCATCTCTGATAGGCAGAGGTGAGGGTTAGGGAAGGAAGCTGTAGTCTAGCTAGCTAGAGCT GCTGGAATAGACATGACAATGGCTGCTGCCAAACTGTTTTCTCTTCTGAGGACAGATGTCCCGTGCAAGT GGCTTGGTGGAAGGGACTAGTGTCTCTAATATAGGGTGATTTATAAGCAGGAAAGTGTGTCCTAGAAATT CAGACCAGAGTGATAGATTGGAATTGGATCATGGGGGACTCATTGAATGTTATTTATTGTATTTGTTTTT GCGATCAGTGTTAGTAAAGTGTCAAAGGGATTGAGCAGATGAGTGACATCATGCAACACAAGTTTTGAGT TTCACTTGTCAGACTGACTGGAGAGGGGCCTGGTTAGTTACAGGAAGGTAATTTGGCATGCAGCCACTAT TTTTGAGTTGATGCAAGCCTCTCTGTATGGAGAGCTGGTCTCCTTTATCCTGTGGGAAAAGAGAACAAAG GAGCATGGGAGTGTTCAAGGGAAGGAGAAATAAAGGGCAGAGAGGCAGCGGTGGTGTCAGGGGAAGCCCA CAGGAGTTAACAGCAGGGTTGCCTCAACCTAGAGAGGAAGCGACCTGGTGCCCTCGGCTCTGTGGCTTCC TTCATCTAACAACATCTTCCACTCTACAACAATGCCAGGGAAGGCGGAGGCTGGTACAGTGCATCAAGAC ACAGCTACTCCTGGGTGACAGAGGTTCAGGGCCAGCTCACTAAGTAGGCAGAAGTTTTTGACATATACTT TGAGAGATAAAGCAAGATTCTGTACCTCAACCTTCAGAATTTCCCCTACCACTCATTATAGTTCCGGAGC TATATAGCTCCTATCATTCTATCATAACCTTAGAATACCAGAGAACATATCATCTCATCTAATTATCTCT TACTATATGTGAAAAAAATGAAGGACATGGGGGAAGTGTGACTTGCCCCAAATCACATATTTCATGGTAG AGCCAGGTCTTCTGTTTGTCATATCAGTGTTCTTCCTGCCACAACCATCTTGAAGAATCTATTTCTCAGT AAGAAAATATCTTTATGGAGAGTAGCTGGAAAACAGTTGAGAGATGGAGGGGAGGCTGGGGGTGTGGAGA GGGGAAGGGGTAAGTGATAGATTCGTTGAAGGGGGGAGAAAAGGCCGTGGGGATGAAGCTAGAAGGCAGA AGGGCTTGCCTGGGCTTGGCCATGAAGGAGCATGAGTTCACTGAGTTCCCTTTGGCTTTTCCATGCTAGC AATGCACGTGGCCCAGCCTGCTGTGGTACTGGCCAGCAGCCGAGGCATCGCCAGCTTTGTGTGTGAGTAT GCATCTCCAGGCAAAGCCACTGAGGTCCGGGTGACAGTGCTTCGGCAGGCTGACAGCCAGGTGACTGAAG TCTGTGCGGCAACCTACATGATGGGGAATGAGTTGACCTTCCTAGATGATTCCATCTGCACGGGCACCTC CAGTGGAAATCAAGTGAACCTCACTATCCAAGGACTGAGGGCCATGGACACGGGACTCTACATCTGCAAG GTGGAGCTCATGTACCCACCGCCATACTACCTGGGCATAGGCAACGGAACCCAGATTTATGTAATTGGTG AGCAAAGCCATTTCACTGAGTTGACACCTGTTGCATTGCAGTCTTCTATGCACAAAAACAGTTTTGTTCC TTAATTTCAGGAGGTTTACTTTTAGGACTGTGGACATTCTCTTTAAGAGTTCTGTACCACATGGTAGCCT TGCTTATTGTGGGTGGCAACCTTAATAGCATTCTGACTGTAAAATAAAATGATTTGGGGAAGTTGGGGCT CTCGCTCTGGAGTGCTAACCATCATGACGTTTGATCTGTACTTTTGATATGATATGATGCTCCTGGGGAA GTAGTCCCAAATAGCCAAACCTATTGGTGGGCTACCCATGCAATTTAGGGGTGGACCTCAAGGCCTGGAA GCTCTAATGTCCTTTTTTCACCAATGTTGGGGAGTAGAGCCCTAGAGTTTAAAACTGTCTCAGGGAGGCT CTGCTTTGTTTTCTGTTGCAGATCCAGAACCGTGCCCAGATTCTGACTTCCTCCTCTGGATCCTTGCAGC AGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTGTTTCTTTGAGCAAAATGGTGAGTGTG GTGCTGATGGTGCACCATGTCTGATGGGGATACCTTTAGTGGTATCAACTGGCCAAAAGATGATGTTGAG TTTAGTGTTCTTGAGATGAGATGAGGCAATAAATGAAGAGGAAGGACAGTGGTAAAGAACGCACTAGAAC CGTAGGCATTGGCATTTGAGGTTTCAGAATGACTAATATTTTAGATGAATTTGTTTGACATTGAATGTTC ATGTGCTTCTGAGCAGGGTTTCAATTTGAGTAACCGTTGCAATAACATGGGGCAGCTGTTTTGCTCTTTG TCTTCATGACAACTGTACTTAAGCTAACAGCCCTGAAACATGAGATTAGGCTGGGCAGAATGCTGCTAGA GAGGACCACTTGGATGGTCTTTATTCTCCTTCTCCATGTCCCTCTCCATCACCTGGAAGTCACCTCTGGG TGCCACTCTGGTGCCTTCCTTGTCGAAGCTGTAGCTGCTCACATGACACCTATCCCTGTTATCCAGTTTG CTTGACTGGGACGTTTTGCCTTCCCCTTCAGCCAGGAAGTGAAAGTCCCAGTTTTTATTTATCACAGGTG TTGGTATTGGTGGTAGAAGAGGTAGAATTATGGAATCAGGCCTCCTGTCAGGATTTCTTTTTGACAGTCC CTCTCAGACACCTCTGCCTAAGGCCAGCTTTGCCATTACAAACTCTCCCTTCTCCCTCTCTCCCTTCTTC TCTTCCTCTTCCTTCTTCTCGCTCTTTCTCTCTCTCTCTTTCTCCCTCTCTGTCTCTTATACACATACAC AAAGATATACTCTATTCCAACATCCTCTACCCAACCTGACAGAGATGTCCTTTGCTGTAGGTTCAGCAGT GGGGATGAGAAATACAGCTCTCAAACAGGATAACTAAAGCTTATTATCTTATCAAGCTTGTTCCCTTGCA GACAAGATTGATCAATTATCATAGGCTTTCTGGGTGTTCTTTCTGAAGCTTTCTCAAAGTCTCTTTCTCC TATCTTCCATTCAAGGCAAATGATTGCCATTTAACATCAAAATCACAGTTATTTATCTAAAATAAATTTT AATAGCTGAATCAAGAAAATCTCCTGAGGTTTATAATTCTGTATGCTGTGAACATTCATTTTTAACCAGC TAGGGACCCAATATGTGTTGAGTTCTATTATGGTTAGAAGTGGCTTCCGTATTCCTCAGTAGTAATTACT GTTTCTTTTTGTGTTTGACAGCTAAAGAAAAGAAGCCCTCTTACAACAGGGGTCTATGTGAAAATGCCCC CAACAGAGCCAGAATGTGAAAAGCAATTTCAGCCTTATTTTATTCCCATCAATTGAGAAACCATTATGAA GAAGAGAGTCCATATTTCAATTTCCAAGAGCTGAGGCAATTCTAACTTTTTTGCTATCCAGCTATTTTTA TTTGTTTGTGCATTTGGGGGGAATTCATCTCTCTTTAATATAAAGTTGGATGCGGAACCCAAATTACGTG TACTACAATTTAAAGCAAAGGAGTAGAAAGACAGAGCTGGGATGTTTCTGTCACATCAGCTCCACTTTCA GTGAAAGCATCACTTGGGATTAATATGGGGATGCAGCATTATGATGTGGGTCAAGGAATTAAGTTAGGGA ATGGCACAGCCCAAAGAAGGAAAAGGCAGGGAGCGAGGGAGAAGACTATATTGTACACACCTTATATTTA CGTATGAGACGTTTATAGCCGAAATGATCTTTTCAAGTTAAATTTTATGCCTTTTATTTCTTAAACAAAT GTATGATTACATCAAGGCTTCAAAAATACTCACATGGCTATGTTTTAGCCAGTGATGCTAAAGGTTGTAT TGCATATATACATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTT AATTTGATAGTATTGTGCATAGAGCCACGTATGTTTTTGTGTATTTGTTAATGGTTTGAATATAAACACT ATATGGCAGTGTCTTTCCACCTTGGGTCCCAGGGAAGTTTTGTGGAGGAGCTCAGGACACTAATACACCA GGTAGAACACAAGGTCATTTGCTAACTAGCTTGGAAACTGGATGAGGTCATAGCAGTGCTTGATTGCGTG GAATTGTGCTGAGTTGGTGTTGACATGTGCTTTGGGGCTTTTACACCAGTTCCTTTCAATGGTTTGCAAG GAAGCCACAGCTGGTGGTATCTGAGTTGACTTGACAGAACACTGTCTTGAAGACAATGGCTTACTCCAGG AGACCCACAGGTATGACCTTCTAGGAAGCTCCAGTTCGATGGGCCCAATTCTTACAAACATGTGGTTAAT GCCATGGACAGAAGAAGGCAGCAGGTGGCAGAATGGGGTGCATGAAGGTTTCTGAAAATTAACACTGCTT GTGTTTTTAACTCAATATTTTCCATGAAAATGCAACAACATGTATAATATTTTTAATTAAATAAAAATCT GTGGTGGTCGTTT
Protein Sequence	>NP_001032720.1 cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM [Homo sapiens] MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVR VTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYY LGIGNGTQIYVIAKEKKPSYNRGLCENAPNRARM
Molecule Role	Protective antigen
Molecule Role Annotation	A clinical trial in patients who previously received autologous tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GVAX; Cell Genesys, South San Francisco, CA, USA) with periodic infusions of CTLA-4 blocking antibodies was cobducted. This sequential treatment resulted in clinically significant anti-tumor immunity without grade 3 or 4 toxicity in most patients. Pathological analyses following treatment of pre-existing tumors revealed a linear correlation between tumor necrosis and the ratio of intra-tumoral CD8+ effector cells to FoxP3+ regulatory cells (T(regs)) (Hodi, 2010).
Related Vaccines(s)	Allogeneic Large Multivalent Immunogen Breast Cancer Vaccine , ALVAC-hB7.1 , AML mRNA Positive Lysate Loaded Autologous Dendritic Cell Vaccine , Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine , Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine , GVAX Cancer Vaccine , GVAX Pancreatic Cancer Vaccine , ICT-121 Dendritic Cell Vaccine , Sargramostim Plasmid DNA Melanoma Vaccine Adjuvant
References

CTLA4