• Vaccine Name: rS.C-APP-ApxI/ApxII
• Target Pathogen: Actinobacillus pleuropneumoniae
• Target Disease: porcine pleuropneumonia
• Vaccine Ontology ID: VO_0004785
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• apxIA gene engineering:
  • Type: Recombinant vector construction
  • Description: S. cerevisiae expressing either ApxI or ApxII (Shin et al., 2013).
  • Detailed Gene Information: Click Here.
• apxIIA gene engineering:
  • Type: Recombinant vector construction
  • Description: S. cerevisiae expressing either ApxI or ApxII (Shin et al., 2013).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001122
  • Description: (Shin et al., 2013)
• Preparation: The surface-displayed ApxIIA#5 expressing S. cerevisiae and the ApxIA expressing S. cerevisiae (Shin et al., 2013).
• Immunization Route: Oral immunization

Pig Response

• Vaccination Protocol: Three groups were designated as the untreated pigs (n = 5, control), the pigs fed with the vector-only S. cerevisiae (n = 5, vector control), and the experimental pigs fed with the ApxIA expressing S. cerevisiae and the surface-displayed ApxIIA#5 expressing S. cerevisiae at a time (n = 10, vaccinated group), respectively. The yeast vaccines were followed by three-time administrations with ApxIA (1.5 × 109 CFU) and ApxIIA (1.5 × 109 CFU) with one week interval (Shin et al., 2013).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The pigs were challenged intranasally one week after final vaccination with a dose (1.5 × 10^9 CFU) of A. pleuropneumoniae serotype 5 Korean isolate from a pig with porcine pleuropneumonia (Shin et al., 2013).
• Efficacy: The vaccinated pigs showed higher specific IgG- and IgA-related antibody activities than the non-treated control and vector control pigs. Additionally, the induced immune responses were found to protect pigs infected with A. pleuropneumoniae according to the analysis of clinical signs and the gross and microscopic pulmonary lesions (Shin et al., 2013).