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Vaccine Detail

Marek's Disease Virus Vaccine rFPV/gI
Vaccine Information
  • Vaccine Name: Marek's Disease Virus Vaccine rFPV/gI
  • Target Pathogen: Marek's disease virus
  • Target Disease: Marek's disease
  • Vaccine Ontology ID: VO_0011392
  • Type: Recombinant vector vaccine
  • Status: Research
  • MDV095 gene engineering:
    • Type: Recombinant vector construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: wing web (ww) and intra-abdominal (i.a.) routes
Host Response

Chicken Response

  • Vaccination Protocol: Groups of 17 chickens were vaccinated at 1 day of age with variable dosage from 101 to 106 plaque-forming units (PFU) of rFPV vaccines by both the wing web (ww) and intra-abdominal (i.a.) routes in trial 1. Monovalent vaccines of either SB-1 or HVT were administered to chickens by the i.a. route at a dose of 2000 PFU. For rFPV + MDV vaccines, each component was administered by a separate inoculation. The ab+ chickens were used in all the experiments (Lee et al., 2003).
  • Challenge Protocol: At 6 days posthatch, groups of vaccinated and unvaccinated chickens were challenged by i.a. inoculation of 500 PFU of strain Md5. Mortality during the course of the experiment was recorded, and chickens were examined for gross MD lesions (Lee et al., 2003).
  • Efficacy: rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
References
Lee et al., 2003: Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S. Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus. Avian diseases. 2003; 47(3); 549-558. [PubMed: 14562881].