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MDV095

Gene Name MDV095
Sequence Strain (Species/Organism) Gallid alphaherpesvirus 2
VO ID VO_0011165
NCBI Gene ID 4811454
NCBI Protein GI 125745128
Locus Tag MD5V_095
Genbank Accession AF243438
Protein Accession YP_001034012
Taxonomy ID 10390
Gene Starting Position 161182
Gene Ending Position 164094
Gene Strand (Orientation) +
Protein Name envelope glycoprotein I
Protein pI 6.7
Protein Weight 37988.3
Protein Length 355
Protein Note envelope glycoprotein I; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; envelope glycoprotein E and glycoprotein I form a heterodimer that play important roles in virus cell-to-cell spread
DNA Sequence
>NC_002229.3:161182-164094 Gallid herpesvirus 2, complete genome
GATGTATCTACTACAATTATTATTTTGGATCCGCCTCTTTCGAGGCATCTGGTCTATAGTTTATACTGGA
ACATCTGTTACGTTATCAACGGACCAATCTGCTCTTGTTGCGTTCTGCGGATTAGATAAAATGGTGAATG
TACGCGGCCAACTTTTATTCCTGGGCGACCAGACTCGGACCAGTTCTTATACAGGAACGACGGAAATCTT
GAAATGGGATGAAGAATATAAATGCTATTCCGTTCTACATGCGACATCATATATGGATTGTCCTGCTATA
GACGCCACGGTATTCAGAGGCTGTAGAGACGCTGTGGTATATGCTCAACCTCATGATAGAGTACAACCTT
TTCCCGAAAAGGGAACATTGTTGAGAATTGTCGAACCCAGAGTATCAGATACAGGCAGCTATTACATACG
TGTAGCTCTCGCTGGAAGAAATATGAGCGATATATTTAGAATGGCTGTTATTATAAGGAGTAGCAAATCT
TGGGCCTGTAATCACTCTGCTAGTTCATTTCAGGCCCATAAATGTATTCGCTATGTCGACCGTATGGCCT
TTGAAAATTATCTGATTGGACATGTAGGCAATTTGCTGGACAGTGACTCGGAATTGCATGCAATTTATAA
TATTACTCCCCAATCCATTTCCACAGATATTAATATTATAACGACTCCATTTTACGATAATTCGGGAACA
ATTTATTCACCTACGGTTTTTAATTTGTTTAATAACAATTCCCATGTCGATGCAATGAATTCGACTGGTA
TGTGGAATACCGTTTTAAAATATACCCTTCCAAGGCTTATTTACTTTTCTACGATGATTGTACTATGTAT
AATAGCATTGGCAATTTATTTGGTCTGTGAAAGGTGCCGCTCTCCCCATCGTAGGATATACATCGGTGAA
CCAAGATCTGATGAGGCCCCACTCATCACTTCTGCAGTTAACGAATCATTTCAATATGATTATAATGTAA
AGGAAACTCCTTCAGATGTTATTGAAAAGGAGTTGATGGAAAAACTGAAGAAGAAAGTCGAATTGTTGGA
AAGAGAAGAATGTGTATAGGTTTGAGAAACTATTATAGGTAGGTGGTACCTGTTAGCTTAGTATAAGGGG
AGGAGCCGTTTCTTGTTTTAAAGACACGAACACAAGGCAGTAAGTTTTATATGTGAATTTTGTGCATGTC
TGCGAGTCAGCGTCATAATGTGTGTTTTCCAAATCCTGATAATAGTGACGACGATCAAAGTAGCTGGAAC
GGCCAACATAAATCATATAGACGTTCCTGCAGGACATTCTGCTACAACGACGATCCCGCGATATCCACCA
GTTGTCGATGGGACCCTTTACACCGAGACGTGGACATGGATTCCCAATCACTGCAACGAAACGGCAACAG
GCTATGTATGTCTGGAAAGTGCTCACTGTTTTACCGATTTGATATTAGGAGTATCCTGCATGAGGTATGC
GGATGAAATCGTCTTACGAACTGATAAATTTATTGTCGATGCGGGATCCATTAAACAAATAGAATCGCTA
AGTCTGAATGGAGTTCCGAATATATTCCTATCTACGAAAGCAAGTAACAAGTTGGAGATACTAAATGCTA
GCCTACAAAATGCGGGTATCTACATTCGGTATTCTAGAAATGGGACGAGGACTGCAAAGCTGGATGTTGT
TGTGGTTGGCGTTTTGGGTCAAGCAAGGGATCGCCTACCCCAAATGTCCAGTCCTATGATCTCATCCCAC
GCCGATATCAAGTTGTCATTAAAAAACTTTAAAGCATTAGTATATCACGTGGGAGATACTATCAATGTCT
CGACGGCGGTTATACTAGGACCTTCTCCGGAGATATTCACATTGGAATTTAGGGTGTTGTTCCTCCGTTA
TAATCCAACGTGCAAGTTCGTCACGATTTATGAACCTTGTATATTTCACCCCAAAGAACCAGAGTGTATT
ACTACTGCAGAACAATCGGTATGTCATTTCGCATCCAACATTGACATTCTGCAGATAGCCGCCGCACGTT
CTGAAAATTGTAGCACAGGGTATCGTAGATGTATTTATGACACGGCTATCGATGAATCTGTGCAGGCCAG
ATTAACATTCATAGAACCAGGAATTCCTTCCTTTAAAATGAAAGATGTCCAGGTAGACGATGCTGGATTG
TATGTGGTTGTGGCTTTATACAATGGACGTCCAAGTGCATGGACTTACATTTATTTGTCAACGGTGGAAA
CATATCTTAATGTATATGAAAACTACCACAAGCCGGGATTTGGGTATAAATCATTTCTACAGAACAGTAG
TATCGTCGACGAAAATGAGGCTAGCGATTGGTCCAGCTCGTCCATTAAACGGAGAAATAATGGTACTATC
ATTTATGATATTTTACTCACATCGCTATCAATTGGGGCGATTATTATCGTCATAGTAGGGGGTGTTTGTA
TTGCCATATTAATTAGGCGTAGGAGACGACGTCGCACGAGGGGGTTATTCGATGAATATCCCAAATATAT
GACGCTACCAGGAAACGATCTGGGGGGCATGAATGTACCGTATGATAATACATGCTCTGGTAACCAAGTT
GAATATTATCAAGAAAAGTCGGCTAAAATGAAAAGAATGGGTTCGGGTTATACCGCTTGGCTAAAAAATG
ATATGCCGAAAATTAGGAAACGCTTAGATTTATACCACTGATATGTACATATTTAAACTTAATGGGATAT
AGTATATGGACGTCTATATGACGAGAGTAAATAAACTGACACTGCAAATGAAGCTGATCTATATTGTGCT
TTATATTGGGACAAACCACTCGCACAAGCTCATTCAACACATCCACTCTTGCTATTAAATTCCCCATTAT
ATAACAATACTGACATAACACTCATATTAAGGGGAGAAAATAA

Protein Sequence
>YP_001034012.1 envelope glycoprotein I [Gallid alphaherpesvirus 2]
MYLLQLLFWIRLFRGIWSIVYTGTSVTLSTDQSALVAFCGLDKMVNVRGQLLFLGDQTRTSSYTGTTEIL
KWDEEYKCYSVLHATSYMDCPAIDATVFRGCRDAVVYAQPHDRVQPFPEKGTLLRIVEPRVSDTGSYYIR
VALAGRNMSDIFRMAVIIRSSKSWACNHSASSFQAHKCIRYVDRMAFENYLIGHVGNLLDSDSELHAIYN
ITPQSISTDINIITTPFYDNSGTIYSPTVFNLFNNNSHVDAMNSTGMWNTVLKYTLPRLIYFSTMIVLCI
IALAIYLVCERCRSPHRRIYIGEPRSDEAPLITSAVNESFQYDYNVKETPSDVIEKELMEKLKKKVELLE
REECV

Molecule Role Protective antigen
Molecule Role Annotation Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
Related Vaccines(s) Marek's Disease Virus Vaccine rFPV/gI
References