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Vaccine Detail
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B. pseudomallei Subunit PotF Protein Vaccine |
| Vaccine Information |
- Vaccine Name: B. pseudomallei Subunit PotF Protein Vaccine
- Target Pathogen: Burkholderia pseudomallei
- Target Disease: Melioidosis
- Vaccine Ontology ID: VO_0011438
- Type: Subunit vaccine
- Status: Research
- PotF
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: Female 5- to 6-week-old BALB/c mice were immunized with the purified recombinant PotF protein given with adjuvant (Harland et al., 2007).
- Challenge Protocol: Mice immunized with the PotF protein or appropriate controls were challenged with B. pseudomallei K96243 on day 70 (Harland et al., 2007).
- Efficacy: Immunization with the PotF protein domain afforded significant protection against a subsequent challenge with B. pseudomallei (Harland et al., 2007).
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| References |
Harland et al., 2007: Harland DN, Chu K, Haque A, Nelson M, Walker NJ, Sarkar-Tyson M, Atkins TP, Moore B, Brown KA, Bancroft G, Titball RW, Atkins HS. Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infection and immunity. 2007; 75(8); 4173-4180. [PubMed: 17517877].
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