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Vaccine Detail
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C. posadasii Subunit PMP1 Protein Vaccine |
| Vaccine Information |
- Vaccine Name: C. posadasii Subunit PMP1 Protein Vaccine
- Target Pathogen: Coccidioides spp.
- Target Disease: Coccidioidomycosis (California disease, Desert rheumatism, San Joaquin valley fever, and Valley fev
- Vaccine Ontology ID: VO_0011460
- Type: Subunit vaccine
- Status: Research
- pmp1
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant: monophosphoryl lipid A vaccine adjuvant
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Host Strain: C57BL/6
- Vaccination Protocol: Mice were immunized subcutaneously with 1, 5, or 50 μg rPmp1 with monophosphoryl lipid A-stable emulsion (MPL-SE) adjuvant on day 0 and day 14. Control mice received adjuvant only (Orsborn et al., 2006).
- Challenge Protocol: Four weeks after boosting (day 42), the mice were infected intraperitoneally with 310 arthroconidia and sacrificed 2 weeks later (Orsborn et al., 2006).
- Efficacy: Vaccination with PMP1 elicited significant protection in mice and a reduction in colonization of organs by Coccidioides (Orsborn et al., 2006).
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| References |
Orsborn et al., 2006: Orsborn KI, Shubitz LF, Peng T, Kellner EM, Orbach MJ, Haynes PA, Galgiani JN. Protein expression profiling of Coccidioides posadasii by two-dimensional differential in-gel electrophoresis and evaluation of a newly recognized peroxisomal matrix protein as a recombinant vaccine candidate. Infection and immunity. 2006; 74(3); 1865-1872. [PubMed: 16495561].
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