• Vaccine Name: S. equi Subunit CNE Protein Vaccine
• Target Pathogen: Streptococcus equi
• Target Disease: Strangles (also equine distemper)
• Vaccine Ontology ID: VO_0011546
• Type: Subunit vaccine
• Status: Research
• collagen binding, ancillary pilus subunit Cne gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant: Matrix-S vaccine adjuvant
  • Adjuvant name: Matrix-S vaccine adjuvant
  • VO adjuvant ID: VO_0001324
• Immunization Route: Intranasally

Mouse Response

• Host Strain: NMRI mice
• Vaccination Protocol: Fifteen to twenty microgram of each antigen and 10 μg of the adjuvant in a total volume of 12–16 μl were given to the mice by placing the antigens onto the nares and allowing the mice to inhale. This was done at three occasions at 1-week intervals. In each experiment, control animals were given only adjuvant at the same concentration omitting the antigen (Flock et al., 2006).
• Challenge Protocol: A dose containing 10^6 CFU in a 10-μl volume was used for infection of mice (Flock et al., 2006).
• Efficacy: Mice immunized with recombinant CNE lost less weight and had less nasal colonization than the unvaccinated controls (Flock et al., 2006).