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collagen binding, ancillary pilus subunit Cne
Gene Name	collagen binding, ancillary pilus subunit Cne
Sequence Strain (Species/Organism)	Streptococcus equi subsp. equi 4047
VO ID	VO_0011213
NCBI Gene ID	7695900
NCBI Protein GI	225870316
Locus Tag	SEQ_0935
Genbank Accession	FM204883
Protein Accession	YP_002746263
Other Database IDs	CDD:283410 CDD:212461 CDD:273478
Taxonomy ID	553482
Gene Starting Position	914185
Gene Ending Position	916158
Gene Strand (Orientation)	?
Protein Name	collagen binding, ancillary pilus subunit Cne
Protein pI	6.61
Protein Weight	68135.68
Protein Length	657
Protein Note	Collagen binding domain; pfam05737
DNA Sequence	>NC_012471.1:914185-916158 Streptococcus equi subsp. equi 4047, complete genome TTTGAAACAACTGACAAAGATCGTTAGTGTGGTCTTGTTGCTGGTCTTTACCCTTAGTGCTAGCCTGCAC AAGGTTCGGGCAACTAATCTTAGTGACAACATCACATCATTGACGGTTGCTTCTTCATCACTCCGAGATG GAGAGAGAACGACGGTAAAGGTTGCGTTTGATGACAAAAAACAGAAAATCAAGGCAGGGGATACGATAGA GGTCACCTGGCCTACAAGTGGTAATGTCTACATTCAGGGCTTTAATAAAACCATACCGCTTAATATTAGA GGGGTAGATGTTGGTACCTTGGAGGTCACGCTAGACAAGGCTGTTTTCACATTCAATCAAAATATTGAAA CAATGCATGATGTCTCTGGTTGGGGAGAGTTTGATATTACTGTTAGAAATGTGACACAAACCACCGCTGA AACATCAGGAACGACCACAGTAAAGGTAGGCAATCGCACTGCTACTATCACTGTTACTAAGCCTGAGGCA GGCACTGGTACCAGCTCATTTTATTATAAGACTGGTGATATGCAGCCCAATGATACTGAGCGTGTGAGAT GGTTCCTGCTGATTAACAACAACAAGGAATGGGTGGCCAATACTGTTACAGTCGAAGACGATATTCAAGG TGGTCAAACCTTGGATATGAGCAGCTTTGACATCACCGTATCTGGTTATCGTAACGAGCGCTTCGTTGGG GAAAACGCTCTGACAGAGTTTCATACAACATTTCCAAATTCTGTCATTACGGCAACAGATAATCACATTA GTGTGCGGTTAGATCAATATGATGCCTCACAAAACACTGTCAACATTGCTTATAAGACAAAGATAACGGA CTTTGACCAAAAAGAATTTGCCAACAACAGTAAAATCTGGTACCAGATTTTATACAAGGATCAGGTATCG GGTCAAGAGTCAAACCACCAAGTAGCCAATATCAATGCTAACGGCGGGGTTGATGGCAGTCGCTATACCA GCTTTACTGTCAAGAAAATTTGGAATGACAAGGAAAATCAAGACGGTAAGCGTCCAAAGACTATTACTGT TCAGCTTTACGCCAATGATCAGAAAGTTAATGATAAGACCATTGAATTGAGTGATACTAATAGCTGGCAA GCAAGTTTTGGTAAGCTGGATAAGTATGACAGTCAGAACCAAAAAATTACCTACAGTGTCAAGGAAGTGA TGGTTCCTGTTGGCTACCAATCGCAGGTTGAGGGGGATAGTGGAGTAGGATTTACCATTACCAACACCTA TACACCAGAGGTCATTAGCATTACCGGTCAAAAAACTTGGGACGACAGGGAAAACCAAGACGGTAAACGT CCTAAGGAGATTACGGTTCGTTTATTGGCAAATGACGCTGCAACTGACAAGGTAGCAACTGCTTCAGAGC AAACCGGCTGGAAGTATACATTTACCAATCTACCGAAATACAAAGATGGTAAACAGATCACCTACACGAT CCAAGAGGACCCTGTGGCAGATTACACCACAACCATTCAGGGATTTGATATTACCAATCATCATGAGGTA GCCTTGACCAGCCTAAAGGTCATCAAGGTTTGGAATGATAAGGACGATTATTACCATAAACGTCCCAAGG AGATTACCATTTTGCTAAAGGCAGATGGCAAGGTGATTCGTGAACATCAGATGACACCGGATCAGCAAGG AAAATGGGAATACACCTTTGACCAGCTGCCGGTCTATCAGACAGGCAAGAAAATCAGCTACAGCATTGAG GAAAAACAGGTTGCTGGCTATCAAGCCCCTGTCTATGAGGTTGATGAAGGCTTGAAGCAGGTCACTGTAA CCAACACCCTTAACCCAAGCTACAAGCTGCCTGACACCGGAGGACAAGGAGTGAAATGGTACCTGTTAAT CGGTGGCGGTTTTATCATCGTCGCAATCCTTGTACTGATCAGCCTTTATCAAAAACACAAGCGCCATAAC ATGTCAAAACCATA
Protein Sequence	>YP_002746263.1 collagen binding, ancillary pilus subunit Cne [Streptococcus equi subsp. equi 4047] MKQLTKIVSVVLLLVFTLSASLHKVRATNLSDNITSLTVASSSLRDGERTTVKVAFDDKKQKIKAGDTIE VTWPTSGNVYIQGFNKTIPLNIRGVDVGTLEVTLDKAVFTFNQNIETMHDVSGWGEFDITVRNVTQTTAE TSGTTTVKVGNRTATITVTKPEAGTGTSSFYYKTGDMQPNDTERVRWFLLINNNKEWVANTVTVEDDIQG GQTLDMSSFDITVSGYRNERFVGENALTEFHTTFPNSVITATDNHISVRLDQYDASQNTVNIAYKTKITD FDQKEFANNSKIWYQILYKDQVSGQESNHQVANINANGGVDGSRYTSFTVKKIWNDKENQDGKRPKTITV QLYANDQKVNDKTIELSDTNSWQASFGKLDKYDSQNQKITYSVKEVMVPVGYQSQVEGDSGVGFTITNTY TPEVISITGQKTWDDRENQDGKRPKEITVRLLANDAATDKVATASEQTGWKYTFTNLPKYKDGKQITYTI QEDPVADYTTTIQGFDITNHHEVALTSLKVIKVWNDKDDYYHKRPKEITILLKADGKVIREHQMTPDQQG KWEYTFDQLPVYQTGKKISYSIEEKQVAGYQAPVYEVDEGLKQVTVTNTLNPSYKLPDTGGQGVKWYLLI GGGFIIVAILVLISLYQKHKRHNMSKP
Molecule Role	Protective antigen
Molecule Role Annotation	Mice were immunised i.n. with collagen-binding protein (CNE) and were subsequently subjected to infection with S. equi subsp. equi. A control group of mice was given only adjuvant. The CNE vaccinated group had a delayed onset of infection compared to the control group. Immunization with CNE led to significant protection from infection (Flock et al., 2006). The antigens used were EAG (alpha2-macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The vaccinated horses showed significantly reduced bacterial growth (p=0.02).(Waller et al., 2007)
Related Vaccines(s)	S. equi Subunit CNE Protein Vaccine
References

collagen binding, ancillary pilus subunit Cne