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Vaccine Detail
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A. pleuropneumoniae OmpW vaccine |
| Vaccine Information |
- Vaccine Name: A. pleuropneumoniae OmpW vaccine
- Target Pathogen: Actinobacillus pleuropneumoniae
- Target Disease: porcine pleuropneumonia
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Host Species as Laboratory Animal Model: Pigs
- ompW
gene engineering:
- Type: Recombinant protein preparation
- Description: The coding sequence of candidate genes were amplified from the genomic DNA of A. pleuropneumoniae JL03. The PCR products were cloned into pET28a and transformed into E. coli DH5α. Positive clones were
transformed into E. coli BL21 (DE3) for expression. OmpW induced relatively higher levels of antibody titers compared with the other proteins, and reached 40% protection in mice. All OmpW-vaccinated pigs
except one developed very mild disease(Chen et al., 2012).
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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| References |
Chen et al., 2012: Chen X, Xu Z, Li L, Chen H, Zhou R. Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Journal of microbiology (Seoul, Korea). 2012; 50(6); 978-986. [PubMed: 23274984].
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