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Vaccine Detail
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PAX3/FKHR Peptide Vaccine |
| Vaccine Information |
- Vaccine Name: PAX3/FKHR Peptide Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007181
- Type: Peptide vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- PAX3
gene engineering:
- FOXO1
gene engineering:
- VEGFA
gene engineering:
- Type: Recombinant protein preparation
- Description: (Fang et al., 2009)
- Detailed Gene Information: Click Here.
- Description: This is for Sarcoma Cancer(NCT00001564). A synthetic peptide vaccine based on the sequences of a translocation mutation of 2 transcriptional factor genes, PAX3 and FKHR. PAX3/FKHR fusion proteins are frequently found in patients with rhabdomyosarcomas. Vaccination with PAX3/FKHR peptide may stimulate the host immune response to elicit a cytotoxic T-cell response against tumor cells that express this PAX3/FKHR fusion protein (Rodeberg et al., 2005; NCIT_C49023).
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| Host Response |
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| References |
Fang et al., 2009: Fang J, Lu Y, Ouyang K, Wu G, Zhang H, Liu Y, Chen Y, Lin M, Wang H, Jin L, Cao R, Roque RS, Zong L, Liu J, Li T. Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo. Clinical and vaccine immunology : CVI. 2009; 16(7); 1033-1039. [PubMed: 19458203].
NCIT_C49023: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49023]
NCT00001564: [https://clinicaltrials.gov/ct2/show/NCT00001564]
Rodeberg et al., 2005: Rodeberg DA, Nuss RA, Heppelmann CJ, Celis E. Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma. Cancer immunology, immunotherapy : CII. 2005; 54(6); 526-534. [PubMed: 15838707].
Shapiro et al., 1993: Shapiro DN, Sublett JE, Li B, Downing JR, Naeve CW. Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer research. 1993; 53(21); 5108-5112. [PubMed: 8221646].
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