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Vaccine Detail
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Telomerase-specific Type 5 Adenovirus OBP-301 Vaccine |
| Vaccine Information |
- Vaccine Name: Telomerase-specific Type 5 Adenovirus OBP-301 Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007080
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- TERT
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Description: This is for Liver Cancer (NCT02293850). A replication-competent oncolytic, telomerase-specific adenovirus serotype 5 (Ad5), with potential antineoplastic activity. OBP-301 contains the human telomerase reverse transcriptase (hTERT) gene promoter sequence that drives the expression of the E1A and E1B genes, and is linked to an internal ribosomal entry site (IRES). Upon administration, OBP-301 selectively infects and replicates in cancer cells that are expressing telomerase, which causes cell lysis. This adenovirus does not infect or replicate in normal, healthy cells. OBP-301 may also potentially be used as a chemosensitizer. hTERT, which encodes for the catalytic protein subunit of telomerase, is overexpressed in a variety of cancer cell types but not in normal, healthy cells. The insertion of an IRES further improves selectivity towards telomerase-expressing cancer cells (Yano et al., 2016; NCIT_C119617).
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| Host Response |
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| References |
NCIT_C119617: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C119617]
NCT02293850: [https://clinicaltrials.gov/ct2/show/NCT02293850?term=OBP-301&rank=1]
Yano et al., 2016: Yano S, Takehara K, Tazawa H, Kishimoto H, Urata Y, Kagawa S, Fujiwara T, Hoffman RM. Efficacy of a Cell-Cycle Decoying Killer Adenovirus on 3-D GelfoamŪ-Histoculture and Tumor-Sphere Models of Chemo-Resistant Stomach Carcinomatosis Visualized by FUCCI Imaging. PloS one. 2016; 11(9); e0162991. [PubMed: 27673332].
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