• Vaccine Name: dVV-HA5(H5N1)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004787
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1)) gene engineering:
  • Type: Recombinant vector construction
  • Description: H5N1 live vaccine, dVV-HA5, expressing the hemagglutinin of a virulent clade 1 H5N1 strain (Mayrhofer et al., 2009).
  • Detailed Gene Information: Click Here.
• HA gene engineering:
  • Type: Recombinant vector construction
  • Description: H5N1 live vaccine, dVV-HA5, expressing the hemagglutinin of a virulent clade 1 H5N1 strain (Mayrhofer et al., 2009).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0000600
  • Description: (Mayrhofer et al., 2009)
• Preparation: Replication-deficient vaccinia virus vector H5N1 live vaccine, dVV-HA5, expressing the hemagglutinin of a virulent clade 1 H5N1 strain (Mayrhofer et al., 2009).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized by intramuscular injections of the indicated doses in a volume of 50 μl in Tris-buffered saline-0.01% human serum albumin buffer (Mayrhofer et al., 2009).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: Immunized mice faced a high-dose challenge with the highly virulent A/Vietnam/1203/2004(H5N1) strain (Mayrhofer et al., 2009).
• Efficacy: A single dose of the defective live vaccine induced complete protection from lethal homologous virus challenge and also full cross-protection against clade 0 and 2 challenge viruses (Mayrhofer et al., 2009).