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Vaccine Detail

ALVAC-NiV-G
Vaccine Information
  • Vaccine Name: ALVAC-NiV-G
  • Target Pathogen: Nipah virus
  • Target Disease: Nipah virus disease
  • Vaccine Ontology ID: VO_0004733
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • F fusion protein gene engineering:
    • Type: Recombinant vector construction
    • Description: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) or the fusion protein (ALVAC-F) (Weingartl et al., 2006).
    • Detailed Gene Information: Click Here.
  • G glycoprotein gene engineering:
    • Type: Recombinant protein preparation
    • Description: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) or the fusion protein (ALVAC-F) (Weingartl et al., 2006).
    • Detailed Gene Information: Click Here.
  • Vector:
  • Preparation: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) (Weingartl et al., 2006).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccination Protocol: Four pigs per group were intramuscularly challenged, with either with 10^8 PFU each or in combination of (ALVAC-NiV-G and ALVAC-NiV-F) (Weingartl et al., 2006).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The pigs were challenged with 2.5 x 10^5 PFU of NiV two weeks later (Weingartl et al., 2006).
  • Efficacy: The combined ALVAC-F/G vaccine induced the highest levels of neutralization antibodies (2,560); despite the low neutralizing antibody levels in the F vaccinees (160), all vaccinated animals appeared to be protected against challenge (Weingartl et al., 2006).
References
Weingartl et al., 2006: Weingartl HM, Berhane Y, Caswell JL, Loosmore S, Audonnet JC, Roth JA, Czub M. Recombinant nipah virus vaccines protect pigs against challenge. Journal of virology. 2006; 80(16); 7929-7938. [PubMed: 16873250].