• Vaccine Name: rvOka-HN (mumps virus)
• Target Pathogen: Mumps virus
• Target Disease: Mumps
• Vaccine Ontology ID: VO_0004709
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HN gene engineering:
  • Type: Recombinant vector construction
  • Description: A recombinant varicella-zoster virus (VZV) Oka vaccine strain (vOka) that contained the mumps virus (MuV) hemagglutinin-neuraminidase (HN) gene, inserted into the site of the ORF 13 gene (Somboonthum et al., 2007).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001059
• Preparation: Recombinant varicella-zoster virus (VZV) Oka vaccine strain (vOka) that contained the mumps virus (MuV) hemagglutinin-neuraminidase (HN) gene, inserted into the site of the ORF 13 gene by using the bacterial artificial chromosome (BAC) system in Escherichia coli (Somboonthum et al., 2007).
• Immunization Route: Intramuscular injection (i.m.)

Guinea pig Response

• Vaccination Protocol: Immunization of guinea pigs with rvOka-HN-induced VZV- and HN-specific antibodies (Somboonthum et al., 2007)
• Vaccine Immune Response Type: VO_0003057
• Efficacy: Interestingly, the induced antibodies had a strong neutralizing activity against virus-cell infections of both MuV and VZV. Therefore, the novel varicella vaccine expressing MuV HN protein is suitable as a polyvalent live attenuated vaccine against VZV and MuV infections (Somboonthum et al., 2007).