• Vaccine Name: HSVT[VP7/6/2]
• Target Pathogen: Rotavirus
• Target Disease: Gastroenteritis
• Vaccine Ontology ID: VO_0004687
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• VP2 gene engineering:
  • Type: Recombinant vector construction
  • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
  • Detailed Gene Information: Click Here.
• VP6 gene engineering:
  • Type: Recombinant vector construction
  • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
  • Detailed Gene Information: Click Here.
• VP7 gene engineering:
  • Type: Recombinant vector construction
  • Description: HSV-1 amplicon vectors encoding individual or multiple structural RV proteins from a polycistronic transgene cassette in mammalian cells (Laimbacher et al., 2012).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001068
• Preparation: Herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 (Laimbacher et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: intramuscular injection of mice with the amplicon vectors as a two-dose regimen without adjuvants (Laimbacher et al., 2012).
• Vaccine Immune Response Type: VO_0001030
• Challenge Protocol: Immunized mice were challenged with live wild-type (wt) rotavirus infection (Laimbacher et al., 2012).
• Efficacy: Immunized mice were partially protected at the mucosal level (Laimbacher et al., 2012).