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Vaccine Detail
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SL3261- UreA and UreB |
| Vaccine Information |
- Vaccine Name: SL3261- UreA and UreB
- Target Pathogen: Helicobacter pylori
- Target Disease: Ulcers
- Vaccine Ontology ID: VO_0004675
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- ureB
gene engineering:
- Type: Recombinant vector construction
- Description: UreA and UreB, two structural subunits of the active enzyme, were expressed in the attenuated Salmonella typhimurium live vaccine SL3261 strain (Gómez-Duarte et al., 1998).
- Detailed Gene Information: Click Here.
- Vector:
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: Oral immunization of mice with urease subunits delivered by an attenuated Salmonella strain induced a specific immune response (Gómez-Duarte et al., 1998).
- Efficacy: Oral immunization of mice with urease subunits delivered by an attenuated Salmonella strain protected mice against H. pylori colonization (Gómez-Duarte et al., 1998).
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| References |
Gómez-Duarte et al., 1998: Gómez-Duarte OG, Lucas B, Yan ZX, Panthel K, Haas R, Meyer TF. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine. 1998; 16(5); 460-471. [PubMed: 9491500].
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