• Vaccine Name: rBCG -Stx2B (Escherichia coli )
• Target Pathogen: Escherichia coli
• Target Disease: Hemorrhagic colitis
• Vaccine Ontology ID: VO_0004657
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• StxB2 gene engineering:
  • Type: Recombinant vector construction
  • Description: A novel vaccine against Shiga toxin (Stx)-producing Escherichia coli (STEC) infection using a recombinant Mycobacterium bovis BCG (rBCG) system expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001023
• Preparation: rBCG expressing the Stx2 B subunit (Stx2B) (Fujii et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: The mice were given Two intraperitoneal vaccinations of rBCG -Stx2B (Fujii et al., 2012).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The mice were orally challenged with 10^3 CFU of STEC strain B2F1 (O91: H21) (Fujii et al., 2012).
• Efficacy: The immunized mice survived statistically significantly longer than the nonvaccinated mice (Fujii et al., 2012).