• Vaccine Name: RB51-SRS2
• Target Pathogen: Neospora caninum
• Target Disease: Neosporosis
• Vaccine Ontology ID: VO_0004648
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• SRS2 gene engineering:
  • Type: Recombinant vector construction
  • Description: Recombinant RB51 strains each expressing SRS2 (RB51/SRS2) or GRA7 (RB51/GRA7) antigens of N. caninum (Alaeddine et al., 2005).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0000020
• Preparation: RB51 strains expressing SRS2 (RB51/SRS2) or GRA7 (RB51/GRA7) antigens of N. caninum (Vemulapalli et al., 2007).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized by single intraperitoneal inoculation of the recombinant RB51 strains (Vemulapalli et al., 2007).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The vaccinated mice were challenged with N. caninum tachyzoites (Vemulapalli et al., 2007).
• Efficacy: Mice vaccinated with strain RB51/SRS2, but not RB51/GRA7, showed significant resistance to cerebral infection when compared to the RB51 vaccinated mice. Interestingly, mice vaccinated with either strain RB51 or RB51/GRA7 also contained significantly lower parasite burden in their brains compared to those inoculated with saline. Mice vaccinated with strain RB51/SRS2 or RB51/GRA7 were protected to the same extent as the strain RB51 vaccinated mice against challenge with B. abortus virulent strain 2308 (Vemulapalli et al., 2007).