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Vaccine Detail

RB51-SRS2
Vaccine Information
  • Vaccine Name: RB51-SRS2
  • Target Pathogen: Neospora caninum
  • Target Disease: Neosporosis
  • Vaccine Ontology ID: VO_0004648
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • SRS2 gene engineering:
    • Type: Recombinant vector construction
    • Description: Recombinant RB51 strains each expressing SRS2 (RB51/SRS2) or GRA7 (RB51/GRA7) antigens of N. caninum (Alaeddine et al., 2005).
    • Detailed Gene Information: Click Here.
  • Vector:
  • Preparation: RB51 strains expressing SRS2 (RB51/SRS2) or GRA7 (RB51/GRA7) antigens of N. caninum (Vemulapalli et al., 2007).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Mice were immunized by single intraperitoneal inoculation of the recombinant RB51 strains (Vemulapalli et al., 2007).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: The vaccinated mice were challenged with N. caninum tachyzoites (Vemulapalli et al., 2007).
  • Efficacy: Mice vaccinated with strain RB51/SRS2, but not RB51/GRA7, showed significant resistance to cerebral infection when compared to the RB51 vaccinated mice. Interestingly, mice vaccinated with either strain RB51 or RB51/GRA7 also contained significantly lower parasite burden in their brains compared to those inoculated with saline. Mice vaccinated with strain RB51/SRS2 or RB51/GRA7 were protected to the same extent as the strain RB51 vaccinated mice against challenge with B. abortus virulent strain 2308 (Vemulapalli et al., 2007).
References
Alaeddine et al., 2005: Alaeddine F, Keller N, Leepin A, Hemphill A. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. The Journal of parasitology. 2005; 91(3); 657-665. [PubMed: 16108562].
Vemulapalli et al., 2007: Vemulapalli R, Sanakkayala N, Gulani J, Schurig GG, Boyle SM, Lindsay DS, Sriranganathan N. Reduced cerebral infection of Neospora caninum in BALB/c mice vaccinated with recombinant Brucella abortus RB51 strains expressing N. caninum SRS2 and GRA7 proteins. Veterinary parasitology. 2007; 148(3-4); 219-230. [PubMed: 17651896].