VIOLIN: Vaccine Investigation and Online Information Network

SRS2
Gene Name	SRS2
Sequence Strain (Species/Organism)	Neospora caninum
VO ID	VO_0011195
NCBI Gene ID	13442869
NCBI Protein GI	5579384
Other Database IDs	CDD:282012
Taxonomy ID	29176
Gene Strand (Orientation)	?
Protein Name	SRS2 surface antigen
Protein pI	4.55
Protein Weight	33921.17
Protein Length	403
Protein Note	SRS domain; pfam04092
Protein Sequence	>AAD45524.1 SRS2 surface antigen, partial [Neospora caninum] NEKFTCLPKQGNADQWEALVYDSQHSITFACDGGTPLPSKLLSEDDGLIVCNESDGEDECEKNAAPLSTF LPGAKKEWVTGTLQQGIKITIPDEHYPATSKAFRVGCKAGKNVCLLNVYVQSRESEVIGQVAHCAYSSNV RLRPITVNPENNGVTLICGPDGKAFPDDYMNHHCTELDECKERPYSAVFPGFSSSFWTGEASGVAGATLT IPKDQFPSTAQTIYLGCTGHPDDKQATCVVPVNIEEVAKPAGAGSNPGGGSQPDQSSEKRDGEQVNKGKP PTGGSGGATTGKQNASQNAKDKGETGGENGDSPVLRGDACDELPSYVALSAASLTA
Molecule Role	Protective antigen
Molecule Role Annotation	NcSAG1 and NcSRS2, the two major immunodominant tachyzoite surface antigens of the apicomplexan parasite Neospora caninum, were investigated for their potential as vaccine candidates in mice. Results suggest that a combined DNA/recombinant antigen-vaccine, based on NcSAG1 and NcSRS2, respectively, exhibited a highly significant protective effect against experimentally induced cerebral neosporosis in mice (Cannas et al., 2003).
Related Vaccines(s)	N. caninum DNA vaccine encoding NcSAG1 and NcSRS2, combined with recombinant NcSAG1 and NcSRS2 Proteins , RB51--MIC3/GRA2/GRA6/MIC1/SRS2 , RB51-SRS2
References