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Vaccine Detail
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T. gondii recombinant vaccine vector rBCGpMV361-TgCyP |
| Vaccine Information |
- Vaccine Name: T. gondii recombinant vaccine vector rBCGpMV361-TgCyP
- Target Pathogen: Toxoplasma gondii
- Target Disease: Toxoplasmosis
- Vaccine Ontology ID: VO_0004602
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: TgCyP(Yu et al., 2013)
- Vector:
- Vector name:
- VO vector ID: VO_0001023
- Description: Mycobacterium bovis is used as a live vaccine vector. This stdy has shown that a "BCG vector expressing a target antigen, TgCyP, represent an alternative system for the production of effective vaccines to prevent toxoplasmosis" (Yu et al., 2013).
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Host Strain: BALB/c mice
- Vaccine Immune Response Type: VO_0003057
- Immune Response: Greater proliferation of CD4+ and CD8+ T cells; levels of Th1-type IFN-γ, IL-2 and IL-12 were significantly increased (Yu et al., 2013)
- Efficacy: rBCGpMV361-TgCyP i.v. inoculation protected the BALB/c mice, as shown by the 17% increased survival rate compared to those mice not inoculated (Yu et al., 2013)
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| References |
Yu et al., 2013: Yu Q, Huang X, Gong P, Zhang Q, Li J, Zhang G, Yang J, Li H, Wang N, Zhang X. Protective immunity induced by a recombinant BCG vaccine encoding the cyclophilin gene of Toxoplasma gondii. Vaccine. 2013; ; . [PubMed: 24176493].
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