• Vaccine Name: Japanese encephalitis virus DNA Vaccine pCJ-3/E encoding E
• Target Pathogen: Japanese encephalitis virus
• Target Disease: Japanese encephalitis
• Vaccine Ontology ID: VO_0004587
• Type: DNA vaccine
• Status: Research
• E gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0001003
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: All mice were immunized intramuscularly at 6 to 8 weeks of age. Groups of five mice were anesthetized and injected three times at 3-week intervals with 100 μg of DNA (Wu et al., 2006).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: The vaccine enhanced the production of higher titers of neutralizing antibodies, and generated both cellular and humoral immunity (Wu et al., 2006).
• Challenge Protocol: For a lethal challenge experiment, C3H/HeN mice were injected intraperitoneally with 50 times the LD50 of JEV Beijing-1 and intracerebrally with PBS (Wu et al., 2006).
• Efficacy: In terms of survival rates of immunized mice challenged with JEV virus at week 16, 100% protection was seen with pCJ-3/E-immunized mice (Wu et al., 2006).