VIOLIN: Vaccine Investigation and Online Information Network

E
Gene Name	E
Sequence Strain (Species/Organism)	Japanese encephalitis virus
VO ID	VO_0011145
NCBI Protein GI	16445023
Other Database IDs	CDD:279241 CDD:213392 CDD:213897
Taxonomy ID	11072
Gene Strand (Orientation)	?
Protein Name	envelope protein
Protein pI	7.88
Protein Weight	49812.26
Protein Length	577
Protein Note	Flavivirus glycoprotein, central and dimerization domains; pfam00869
Protein Sequence	>AAK31640.1 envelope protein, partial [Japanese encephalitis virus] FNCLGMGNRDFIEGASGATWVDLVLEGDSCLTIMANDKPTLDVRMINIEASQLAEVRSYCYHASVTDIST VARCPTTGEAHNEKRADSSYVCKQGFTDRGWGNGCGLFGKGSIDTCAKFSCTSKAIGRTIQPENIKYKVG IFVHGATTSENHGNYSAQVGASQAAKFTVTPNAPSITLKLGDYGEVTLDCEPRSGLNTEAFYVMTVGSKS FLVHREWFHDLALPWTSPSSTAWRNRELLMEFEEAHATKQSVVALGSQEGGLHQALAGAIVVEYSSSVKL TSGHLKCRLKMDKLALKGTTYGMCTEKFSFAKNPADTGHGTVVIELSYSGSDGPCKIPIVSVASLNDMTP VGRLVTVNPFVATSSANSKVLVEMEPPFGDSYIVVGRGDKQINHHWHKAGSTLGKAFSTTLKGAQRLAAL GDTAWDFGSIGGVFNSIGKAVHQVFGGAFRTLFGGMSWITQGLMGALLLWMGVNARDRSIALAFLATGGV LVFLATNVHA
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers constructed a recombinant pseudotype baculovirus encoding the JEV envelope (E) protein and demonstrated that it could elicit high protective immunity in mice. Intramuscular injections of BV-G-E at various doses into mice produced higher levels of JEV-specific neutralizing antibodies, IFN-gamma and better protective efficacy against a lethal challenge with JEV than that of pc-E. Furthermore, BV-G-E could elicit a higher level of cellular immunity response and provide equal protective efficacy against JEV challenge compared to inactivated vaccine (Li et al., 2009).
Related Vaccines(s)	Japanese encephalitis virus DNA vaccine encoding E protein , Japanese encephalitis virus DNA Vaccine P-JEV , Japanese encephalitis virus DNA Vaccine pCJ-3/E encoding E , Japanese encephalitis virus vaccine BV-G-E , NYVAC-JEV- prM/E/ NS1
References

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