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Vaccine Detail
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Marburg virus recombinant vector vaccine MBGV GP/MBGV NP |
| Vaccine Information |
- Vaccine Name: Marburg virus recombinant vector vaccine MBGV GP/MBGV NP
- Target Pathogen: Marburg Virus
- Target Disease: Hemorrhagic fever
- Vaccine Ontology ID: VO_0004566
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Guinea pig, macaques
- GP from Musoke Marburgvirus
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- NP from Marburg virus Musoke
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Immunization Route: subcutaneous injection
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Three monkeys vaccinated with replicons which expressed MBGV GP, and three others vaccinated with both replicons that expressed GP or NP, remained aviremic and were completely protected from disease (Hevey et al., 1998).
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| References |
Hevey et al., 1998: Hevey M, Negley D, Pushko P, Smith J, Schmaljohn A. Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates. Virology. 1998 Nov 10; 251(1); 28-37. [PubMed: 9813200 ].
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