• Vaccine Name: SIV recombinant vector vaccine rAd5/rLCMV
• Target Pathogen: Simian Immunodeficiency Virus
• Target Disease: Simian AIDS
• Vaccine Ontology ID: VO_0004564
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Macaques
• Antigen: a mismatched SIV envelope (Env) gene derived from simian immunodeficiency virus SIVmac239 (Flatz et al., 2012)
• Vector:
  • Vector name:
  • VO vector ID: VO_0001081
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Recombinant adenovirus type 5 (rAd5) prime followed by replication-defective lymphocytic choriomeningitis virus (rLCMV) boost elicited robust CD4 and CD8 T-cell and humoral immune responses. In addition, there was a presence of neutralizing antibodies to the challenge viruses tested in peripheral blood mononuclear cells (Flatz et al., 2012).
• Efficacy: To evaluate the infectibility of immunized and control animals, 10 vaccinated Macaca mulatta animals and 10 controls were challenged intrarectally with SIVsmE660 six weeks after the rLCMV boost. In the vaccinated group, three of the 10 monkeys became infected after 99 challenges (3% infection rate per challenge), while in the control null group, eight of the 10 monkeys were infected after 47 challenges (17% infection rate per challenge), indicating a protective efficacy of 82% per challenge (Flatz et al., 2012).