• Vaccine Name: H. pylori DNA vaccine pcDNA3.1-hspB
• Target Pathogen: Helicobacter pylori
• Target Disease: Ulcers
• Vaccine Ontology ID: VO_0004561
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• Antigen: HspB from H. pylori SS1 (Todoroki et al., 2000)
• hspB gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000158
• Immunization Route: Intracutaneous immunization

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Antibody isotypes were predominantly mixed IgG1/IgG2a (Th0-like) with pcDNA3.1-hspB (Todoroki et al., 2000).
• Efficacy: The inflammation scores were significantly lower in pcDNA 3.1-hspB (16.5% reduction) immunized mice groups than in control group (100%). Colonization with H. pylori was verified histologically. There were a lot of bacteria colonies in the mucous layer of stomachs in all control group mice and fewer in HspB group mice (Todoroki et al., 2000).