• Vaccine Name: L. major DNA vaccine pcLACK + IL-22
• Target Pathogen: Leishmania major
• Target Disease: Cutaneous leishmaniasis
• Vaccine Ontology ID: VO_0004530
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• LACK gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000132
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: IL-22 obviously caused an increase in IFN-γ production and a decrease in IL-4 production before and after the challenge (p < 0.05) (Hezarjaribi et al., 2013).
• Efficacy: Comparison of the mean size of lesions in the LACK and LACK + IL-22 groups demonstrated that the mean size of lesions of the two groups was significantly different from week four (p < 0.05). The survival rate at day 170 after challenge for the PBS, pcDNA3 (empty plasmid), pcLACK (pcDNA3 containing LACK gene), and pcLACK + IL-22 groups were 20%, 40%, 60%, and 80%, respectively (Hezarjaribi et al., 2013).