VIOLIN: Vaccine Investigation and Online Information Network

LACK
Gene Name	LACK
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011260
NCBI Nucleotide GI	1276476
NCBI Protein GI	1276477
Protein Accession	AAA97577.1
Other Database IDs	CDD:238121 CDD:225201 CDD:293791
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	LACK
Protein pI	6.64
Protein Weight	32575.5
Protein Length	354
Protein Note	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200
DNA Sequence	>gi\|1276476\|gb\|U27568.1\|LMU27568 Leishmania major activated protein kinase C receptor homolog LACK mRNA, complete cds AACTAACGCTATATAAGTATCAGTTTCTGTACTTTATTGATAAGTTTCTTCTCACTCCACTTCGTTTCAC CATGAACTACGAGGGTCACCTGAAGGGTCACCGAGGATGGGTCACCTCCCTGGCCTGCCCGCAGCAGGCG GGGTCGTACATCAAGGTGGTGTCGACGTCGCGCGATGGTACGGTCATCTCGTGGAAGGCCAACCCCGACC GCCACAGCGTGGACAGCGACTACGGTCTGCCGAACCACCGCCTCGAGGGCCACACCGGCTTCGTGTCGTG CGTGTCGCTGGCCCACGCCACCGACTACGCGCTGACCGCGTCCTGGGACCGCTCCATCCGCATGTGGGAC CTGCGCAATGGCCAGTGCCAGCGCAAGTTCCTGAAGCACACCAAGGACGTGCTCGCCGTCGCCTTCTCGC CGGACGACCGCCTGATCGTGTCCGCGGGCCGCGACAACGTGATCCGCGTGTGGAACGTGGCGGGTGAGTG CATGCACGAGTTCCTGCGCGACGGCCACGAGGACTGGGTGAGCAGCATCTGCTTCTCGCCGTCGCTGGAG CACCCGATCGTGGTGTCCGGCAGCTGGGACAACACCATCAAAGTATGGAACGTGAACGGGGGCAAGTGTG AGCGCACGCTCAAGGGCCACAGCAACTACGTGTCCACGGTGACGGTGTCGCCAGACGGGTCTCTGTGCGC ATCTGGCGGCAAGGACGGCGCGGCGCTGTTGTGGGACCTGAGCACCGGTGAGCAGCTGTTCAAGATCAAC GTGGAGTCGCCCATCAACCAGATCGGCTTCTCGCCCAACCGCTTCTGGATGTGCGTCGCGACGGAGAGGT CTCTGTCCGTGTACGACCTGGAGAGCAAGGCCGTGATTGCGGAGCTGACGCCGGACGGCGCGAAGCCGTC GGAGTGCATCTCCATTGCCTGGTCCGCCGACGGCAACACTCTGTACTCCGGCCACAAGGACAACCTGATC CGCGTGTGGTCCATCTCCGACGCCGAGTAATGGCCGCGCGCTGCTCGTGCCGGACGGCGTGGTAGGCGAG GGAGAACGAGCGAGAAGTGA
Protein Sequence	>AAA97577.1 LACK [Leishmania major] MNYEGHLKGHRGWVTSLACPQQAGSYIKVVSTSRDGTVISWKANPDRHSVDSDYGLPNHRLEGHTGFVSC VSLAHATDYALTASWDRSIRMWDLRNGQCQRKFLKHTKDVLAVAFSPDDRLIVSAGRDNVIRVWNVAGEC MHEFLRDGHEDWVSSICFSPSLEHPIVVSGSWDNTIKVWNVNGGKCERTLKGHSNYVSTVTVSPDGSLCA SGGKDGAALLWDLSTGEQLFKINVESPINQIGFSPNRFWMCVATERSLSVYDLESKAVIAELTPDGAKPS ECISIAWSADGNTLYSGHKDNLIRVWSISDAE
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers evaluated the potency of different DNA vaccine candidates in BALB/c mice using high dose footpad parasite challenge. A truncated portion of the LACK antigen (LACKp24) was able to induce the highest protective effect compared to other constructs. The DNA vaccine encoding LACK was able to induce partial protection in mice (Ahmed et al., 2009).
Related Vaccines(s)	L. major DNA Vaccine encoding LACKp24, TSA, LmSTI1 and CPa , L. major DNA vaccine encoding TSA, LMSTI1, KMP11, and LACK , L. major DNA vaccine pcLACK + IL-22
References

LACK