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Vaccine Detail
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IHNV DNA vaccine pIHN-G encoding glycoproteins |
| Vaccine Information |
- Vaccine Name: IHNV DNA vaccine pIHN-G encoding glycoproteins
- Target Pathogen: Infectious Hematopoietic Necrosis Virus
- Target Disease: Infectious hematopoietic necrosis
- Vaccine Ontology ID: VO_0004495
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Fish
- G glycoprotein
gene engineering:
- Type: DNA vaccine construction
- Description: The pcDNA3.1(+) vector expressed viral glycoproteins (G proteins) (Lorenzen et al., 2002).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rainbow trout Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Challenge experiments revealed that immunity established shortly after vaccination was cross-protective between IHNV and VHSV whereas no increased survival was found upon challenge with bacterial pathogens. Within two months after vaccination, the cross-protection disappeared while the specific immunity to homologous virus remained high (Lorenzen et al., 2002).
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| References |
Lorenzen et al., 2002: Lorenzen N, Lorenzen E, Einer-Jensen K, LaPatra SE. Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens. Developmental and comparative immunology. 2002; 26(2); 173-179. [PubMed: 11696382].
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