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Vaccine Detail
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C. tetani DNA vaccine pcDNA3tetC encoding fragment C |
| Vaccine Information |
- Vaccine Name: C. tetani DNA vaccine pcDNA3tetC encoding fragment C
- Target Pathogen: Clostridium tetani
- Target Disease: Tetanus
- Vaccine Ontology ID: VO_0004414
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- TTC
gene engineering:
- Type: Recombinant protein preparation
- Description: Vector pcDNA3 expressed fragment C (Anderson et al., 1997).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Anti-Fragment C serum immunoglobulin and proliferative responses in splenocytes were observed following two immunizations with pcDNA3/tetC (Anderson et al., 1997).
- Efficacy: Immunization of mice with Fragment C protein, the non-toxic C-terminal domain of tetanus toxin, protects mice against lethal challenge with tetanus toxin. Seven out of ten immunized mice were protected (Anderson et al., 1997).
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| References |
Anderson et al., 1997: Anderson R, Gao XM, Papakonstantinopoulou A, Fairweather N, Roberts M, Dougan G. Immunization of mice with DNA encoding fragment C of tetanus toxin. Vaccine. 1997; 15(8); 827-829. [PubMed: 9234525].
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