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Vaccine Detail

C. tetani DNA vaccine pcDNA3tetC encoding fragment C
Vaccine Information
  • Vaccine Name: C. tetani DNA vaccine pcDNA3tetC encoding fragment C
  • Target Pathogen: Clostridium tetani
  • Target Disease: Tetanus
  • Vaccine Ontology ID: VO_0004414
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • TTC gene engineering:
    • Type: Recombinant protein preparation
    • Description: Vector pcDNA3 expressed fragment C (Anderson et al., 1997).
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000132
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccine Immune Response Type: VO_0000286
  • Immune Response: Anti-Fragment C serum immunoglobulin and proliferative responses in splenocytes were observed following two immunizations with pcDNA3/tetC (Anderson et al., 1997).
  • Efficacy: Immunization of mice with Fragment C protein, the non-toxic C-terminal domain of tetanus toxin, protects mice against lethal challenge with tetanus toxin. Seven out of ten immunized mice were protected (Anderson et al., 1997).
References
Anderson et al., 1997: Anderson R, Gao XM, Papakonstantinopoulou A, Fairweather N, Roberts M, Dougan G. Immunization of mice with DNA encoding fragment C of tetanus toxin. Vaccine. 1997; 15(8); 827-829. [PubMed: 9234525].