VIOLIN: Vaccine Investigation and Online Information Network

TTC
Gene Name	TTC
VO ID	VO_0010909
NCBI Protein GI	157829735
3D structure: PDB ID	1A8D
Other Database IDs	CDD:285228 CDD:285226
Taxonomy ID	1513
Gene Strand (Orientation)	?
Protein pI	6.63
Protein Weight	50172.35
Protein Length	506
Protein Note	NCBI Domains
Protein Sequence	>pdb\|1A8D\|A Chain A, Tetanus Toxin C Fragment MKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIHLVNNESSEV IVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWT LKDSAGEVRQITFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLK LDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLK NITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPK DGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDPNRDI LIASNWYFNHLKDKILGCDWYFVPTDEGWTND
Molecule Role	Protective antigen
Molecule Role Annotation	The fragment C of tetanus toxin was amplified from Clostridium tetani DNA by PCR. Immunization of mice with rTTC resulted in the production of antibodies that were able to protect mice against a challenge with tetanus toxin furthermore, rTTC in vivo appeared to be able to undergo retrograde axonal transport (He et al., 2000).
Related Vaccines(s)	C. tetani DNA vaccine pcDNA3tetC encoding fragment C
References