• Vaccine Name: Marburg virus DNA prime/boost vaccine DNA/rAd5-GP encoding GP from strain Angola
• Target Pathogen: Marburg Virus
• Target Disease: Hemorrhagic fever
• Vaccine Ontology ID: VO_0004389
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Macaque
• GP from Musoke Marburgvirus gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector rAd type 5 (rAd5) expressed GP of MARV (Geisbert et al., 2010).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005004
• Immunization Route: Intramuscular injection (i.m.)

Macaque Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: The vaccine induced humoral responses , as well as CD4(+) and CD8(+) cellular immune responses, with skewing toward CD4(+) T-cell activity against MARV GP. The highest antibody titers were achieved with a heterologous prime-boost vaccine. rAd5-GP boosted titers in DNA-primed animals more than 2 orders of magnitude to a final prechallenge GP ELISA IgG titer of 1:237,167 (Geisbert et al., 2010).
• Efficacy: Heterologous prime-boost with DNA/rAd vectors generated protective immunity in all subjects after challenge with a lethal dose of MARV Angola (Geisbert et al., 2010).