• Vaccine Name: Francisella tularensis galU mutant vaccine
• Target Pathogen: Francisella tularensis
• Target Disease: Tularemia
• Vaccine Ontology ID: VO_0002844
• Type: Live, attenuated vaccine
• Status: Licensed
• Host Species as Laboratory Animal Model: Mouse
• galU gene engineering:
  • Type: Gene mutation
  • Description: This galU mutant is from Francisella tularensis (Jayakar et al., 2011).
  • Detailed Gene Information: Click Here.
• Immunization Route: intranasal immunization

Mouse Response

• Persistence: A galU mutant is attenuated in mice, inducing only transient weight loss (Jayakar et al., 2011).
• Efficacy: A galU mutant induces protection in mice from challenge with wild type F. tularensis, inducing only transient weight loss (Jayakar et al., 2011).
• Host IL-1b response
  • Description: Twenty four hours after infection of a mouse macrophage-like cell line (THP-1) or BMDCs with the galU mutant, the amount of IL-1β released into culture supernatants was significantly higher than was observed following infection with WT FT (Jayakar et al., 2011).
  • Detailed Gene Information: Click Here.