• Vaccine Name: Burkholderia pseudomallei purN mutant vaccine
• Target Pathogen: Burkholderia pseudomallei
• Target Disease: Melioidosis
• Vaccine Ontology ID: VO_0002828
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• purN gene engineering:
  • Type: Gene mutation
  • Description: This purN mutant is from Burkholderia pseudomallei (Breitbach et al., 2008).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Persistence: A purN mutant was attenuated in mice, as mice did not show any clinical symptoms of illness (Breitbach et al., 2008).
• Efficacy: A purN induced strong protection in mice from challenge with wild type B. pseudomallei (Breitbach et al., 2008).