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Vaccine Detail

Feline immunodeficiency virus ORF-A mutant vaccine

Vaccine Information

Vaccine Name: Feline immunodeficiency virus ORF-A mutant vaccine
Target Pathogen: Feline immunodeficiency virus
Target Disease: Feline AIDS
Vaccine Ontology ID: VO_0002959
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Cat
ORF-A gene engineering:
- Type: Gene mutation
- Description: This ORF-A mutant is from Feline immunodeficiency virus (Pistello et al., 2005).
- Detailed Gene Information: Click Here.
Immunization Route: subcutaneous injection

Host Response

Cat Response

Persistence: An ORF-A is attenuated in cats (Pistello et al., 2005).
Efficacy: An ORF-A mutant induces protection from challenge with wild type FIV (Pistello et al., 2005).

References

Pistello et al., 2005: Pistello M, Bonci F, Isola P, Mazzetti P, Merico A, Zaccaro L, Matteucci D, Bendinelli M. Evaluation of feline immunodeficiency virus ORF-A mutants as candidate attenuated vaccine. Virology. 2005; 332(2); 676-690. [PubMed: 15680433].