VIOLIN: Vaccine Investigation and Online Information Network

ORF-A
Gene Name	ORF-A
Sequence Strain (Species/Organism)	Feline immunodeficiency virus
NCBI Gene ID	1724707
NCBI Protein GI	9626705
Locus Tag	FIVgp4
Genbank Accession	M25381
Protein Accession	NP_040975
Taxonomy ID	11673
Gene Starting Position	5991
Gene Ending Position	6227
Gene Strand (Orientation)	+
Protein Name	hypothetical protein
Protein pI	9.29
Protein Weight	9252.28
Protein Length	78
DNA Sequence	>gi\|9626701:5991-6227 Feline immunodeficiency virus, complete genome AATGGAAGACATAATAGTATTATTCAATAGGGTCACTGAGAAACTAGAAAAAGAATTAGCTATCAGAATA TTTGTATTAGCACATCAATTAGAAAGGGACAAAGCTATTAGATTACTACAAGGATTATTTTGGAGATATA GATTTAAGAAACCCCGAGTAGATTATTGTTTATGTTGGTGGTGTTGCAAATTCTATTATTGGCAGTTGCA ATCTACATTATCAATAACTACTGCTTA
Protein Sequence	>gi\|9626705\|ref\|NP_040975.1\| hypothetical protein FIVgp4 [Feline immunodeficiency virus] MEDIIVLFNRVTEKLEKELAIRIFVLAHQLERDKAIRLLQGLFWRYRFKKPRVDYCLCWWCCKFYYWQLQ STLSITTA
Molecule Role	Virmugen
Molecule Role Annotation	Feline immunodeficiency virus (FIV) made defective in the accessory gene ORF-A were previously shown to be greatly attenuated in its ability to replicate in lymphocytes but to grow normally or near normally in other cell types. 3/9 vaccinees (cats) showed no evidence of the challenge virus over a 15-month observation period. In the other vaccinees, the challenge virus was predominant for various periods of time, but pre-existing viral loads and CD4 lymphocyte counts were either unaffected or altered only marginally and transiently (Pistello et al., 2005).
Related Vaccines(s)	Feline immunodeficiency virus ORF-A mutant vaccine
References

ORF-A