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Vaccine Detail
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Francisella tularensis wbtI mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis wbtI mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Vaccine Ontology ID: VO_0002855
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- WbtI
gene engineering:
- Type: Gene mutation
- Description: This wbtI mutant is from Francisella tularensis (Li et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: .A wbtI mutant is attenuated in mice (Li et al., 2007)
- Efficacy: A wbtI mutant induces protection in mice, especially in higher doses, from challenge with wild type F. tularensis (Li et al., 2007).
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| References |
Li et al., 2007: Li J, Ryder C, Mandal M, Ahmed F, Azadi P, Snyder DS, Pechous RD, Zahrt T, Inzana TJ. Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS. Microbiology (Reading, England). 2007; 153(Pt 9); 3141-3153. [PubMed: 17768257].
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