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WbtI
Gene Name	WbtI
Sequence Strain (Species/Organism)	Francisella tularensis subsp. holarctica FTNF002-00
VO ID	VO_0011074
NCBI Gene ID	5522688
NCBI Protein GI	156502002
Locus Tag	FTA_0635
Genbank Accession	CP000803
Protein Accession	YP_001428067
Taxonomy ID	458234
Gene Starting Position	590832
Gene Ending Position	591914
Gene Strand (Orientation)	+
Protein Name	DegT/DnrJ/EryC1/StrS family sugar aminotransferase
Protein pI	6.8
Protein Weight	37905.36
Protein Length	360
Protein Note	component of putative O antigen gene complex
DNA Sequence	>NC_009749.1:590832-591914 Francisella tularensis subsp. holarctica FTNF002-00, complete genome AATGAGTAAAGTAAATGTAACAAAACCATATTTACCAGATATAAATAAATATAAAAGCTATGTAAATAAA ATATACAAAAATGGATGGCTTACTAATAATGGTCCGTTAGTGCAAGAGCTAGAAAAAAGACTTGCAAAGT ATCTAGGTGTTAAAAATATAGTTTTAGTATCAAATGGTACAATTGCATTAGAAATCGCGTATAGAGCGTT AGGAGTCAAAGGAAGTGCAATTACTACTCCATTTTCATTTGTCGCTACTACATCTTCATTGGTTTCTAAC AATGTAAAACCAGTGTTTGTTGATATTGATGAGAATACTCTAAGTATAGACGTCTCTAAAATTAAGTATG CTATTGAAGAGGATACTTCAGCTATTGTGCCAGTTCATGTGTTTGGAAATGGTTGTGAAGTTGAAAAAAT AGACATGCTGGCTAAAAAACATAACTTAAAAGTTATTTATGATGCAGCACATGCTTTTGATGTTAAGTAT AAGGGTGAGAGTATATTAAACTATGGTGATATTTCGACATTAAGTTTTCATGCAACAAAGATTTTTCATT CTATTGAAGGAGGTGCGCTTATCATTAATGATGATAGTCTTGTTGAAAAAGTTCGTTATTTCATTAATTT TGGTATAGAAAGCTCAGAATCAATACCTTACTTAGGTACTAATGCTAAAATGAATGAATTTGAGGCGGCT ATGGGACTTTGTGTTCTAGATGATATTATAGAAATTAAGAGCAAAAGGAAAGTTATTACAGAGATATATG AGGCTGGGTTAGATGGATTGGTAAAGTTTCAAGAACAGAATCAGCATTCTAGTAGGAATTATAGCTATTT TCCAGTAATATTTAGGACTGAGGAGGAACTTCTCAGAGTACAGAAAGCACTAATACAAAATGATATAATA TCGCGTAGATATTTTTATCCATCATTAGATAGTCTTAGTTATATAGAGCCAAAGCAGTATATGCCAATCT CAAGAGATATATCTAAAAGAATATTATGTTTGCCAATTTATGCAGAGTTAGAAGACGATAAAATTAATAA AATAATTAATAATATCAAAGAGGTTTCCTCATG
Protein Sequence	>YP_001428067.1 DegT/DnrJ/EryC1/StrS family sugar aminotransferase [Francisella tularensis subsp. holarctica FTNF002-00] MSKVNVTKPYLPDINKYKSYVNKIYKNGWLTNNGPLVQELEKRLAKYLGVKNIVLVSNGTIALEIAYRAL GVKGSAITTPFSFVATTSSLVSNNVKPVFVDIDENTLSIDVSKIKYAIEEDTSAIVPVHVFGNGCEVEKI DMLAKKHNLKVIYDAAHAFDVKYKGESILNYGDISTLSFHATKIFHSIEGGALIINDDSLVEKVRYFINF GIESSESIPYLGTNAKMNEFEAAMGLCVLDDIIEIKSKRKVITEIYEAGLDGLVKFQEQNQHSSRNYSYF PVIFRTEEELLRVQKALIQNDIISRRYFYPSLDSLSYIEPKQYMPISRDISKRILCLPIYAELEDDKINK IINNIKEVSS
Molecule Role	Protective antigen
Molecule Role Annotation	Immunization with WbtI(G191V) protected mice against a relatively low-dose intraperitoneal challenge with LVS (F. tularensis subspecies holarctica live vaccine strain), but was less protective against a high-dose challenge (Li et al., 2007).
Additional Molecule Role	Virmugen
Additional Molecule Role Annotation	A wbtI mutant is attenuated in mice. The mutant protected against a low dose challenge with the parental strain, but was less effective against higher doses. However, increasing the immunization dose increased the resistance to higher challenge doses (Li et al., 2007).
Related Vaccines(s)	Francisella tularensis wbtI mutant vaccine
References

WbtI