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Vaccine Detail
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Francisella tularensis purF mutant vaccine |
| Vaccine Information |
- Vaccine Name: Francisella tularensis purF mutant vaccine
- Target Pathogen: Francisella tularensis
- Target Disease: Tularemia
- Vaccine Ontology ID: VO_0002850
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- purF
gene engineering:
- Type: Gene mutation
- Description: This purF mutant is from Francisella tularensis (Quarry et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: A purF mutant is attenuated in mice (Quarry et al., 2007).
- Efficacy: A purF mutant induces significant protection from challenge with wild type F. tularensis (Quarry et al., 2007).
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| References |
Quarry et al., 2007: Quarry JE, Isherwood KE, Michell SL, Diaper H, Titball RW, Oyston PC. A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice. Vaccine. 2007; 25(11); 2011-2018. [PubMed: 17241711].
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