VIOLIN: Vaccine Investigation and Online Information Network

purF
Gene Name	purF
Sequence Strain (Species/Organism)	Francisella novicida U112
NCBI Gene ID	4548578
NCBI Protein GI	118498261
Locus Tag	FTN_1700
Genbank Accession	CP000439
Protein Accession	YP_899311
Taxonomy ID	401614
Gene Starting Position	1820533
Gene Ending Position	1822023
Gene Strand (Orientation)	-
Protein Name	amidophosphoribosyltransferase
Protein pI	7.32
Protein Weight	51173.39
Protein Length	496
Protein Note	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
DNA Sequence	>gi\|118496615:1820533-1822023 Francisella tularensis subsp. novicida U112, complete genome ATTAGTTATCAAACCCTTTGTATTTTTTTTCTAATTCTTTTAACTCTTTACGATGTTTCTCTAGCGCATC TAGATAAGCATCATCGACATCACCTGTAATGTAATTACCAGAGAAAACACTATCCTCAAACTCTCTAATT TTAGGGTTTTGCTTTTGAATAATCTCTTTTAGATCCTCTAATGGTAAATATATTAGTCCATCTACTCCAA TCCACTGGCGAATCTCTTCTATAGTCTTTCCATGAGCAATTAAATCCGACTTAACCGGCATATCAATACC ATAAACATTTGGATAACGAACGGCTGGAGATACTGAAGCAAGATAAACAGATTTAGCACCTAAATCTCTA ATCATCTCAATAATCCGCTTAGATGTTGTACCTCGGACAATAGAATCATCAACAAGTAGAACATTCTTAT CTCTAAACTCTGCTGGAATAGGGTTTAGTTTTCTTCTAACAAAATTCTTTCTATCAACATTCTCTGGCAT GATAAAAGTTCTACCAACATAGCGATTCTTAACAAAACCTTCACGATACTCAACACCTAATGCTGTTGCA ATCTCTTGAGCAGAAGCTCTACCTGTCTCAGGTACAGGGATAACGATATCGATATCCTTATCTTTCCACG CTTCTTTGATTCTCTTACTTAGAATTTTACCAGCATCTACTCGCGCTTGATAAACACTCACACCATTCAT AATACTATCAGGACGTGCAAAGTATACATACTCAAATAGACACGGTGCCAAAACTGGATTTTTTGCACAG ATTTTAGAGTGAACCTTTCTATCCTCTGTAATTATTATCACCTCACCAGGTTCAACATCACGTAATACTT TAAATCCGGAAATATCTAAAGCAACACTTTCACTAGCAACCATGTAAGCTTTTTCACCATCATCGTACTC TTTAAAACCAAGCACAAGTGGACGAATACCATAAGGATCTCTAAAAGCAATTAAACCAAAATTTGCTATC ATCGCAGTACAAGCATAGCCCCCTTTGACATGTTCAAAAACAAATTTACATGCTTTATAAACAGCCTCAG AAGTCGCAGATCCTTTTGATTTATTCATCCCACAAGCAAAGAAATTAAGCAATAATTCGGAATCTGAACT TGTATTAAGATGGCGTCTTTCAATATCATGGAGCATTTGTGCAAGCTCTGGCACATTAGTGAGATTGCCA TTATGAGCAAAGACTATACCATGAGGATTATTTACATAAAAAGGTTGGCTATCAGCAGCACCCAAGCTAC CTGCTGTAGGATATCTAACATGACCGATACCCATATTACCTTTTGACTTCTCTAGTTTTTCATCTGTAAA TACATCACTTACTAGACCTGTATTTTTACGGATAAAAAAGTGCCCACGATCCATAGTTGCAATCCCTGCA GCATCTTGACCTCTATGCTGCAAAAGACTTAAACCATAAAATAATGCATAACTAACCTGATCTGGTCCAG CGACTCCAATTACTCCACACA
Protein Sequence	>gi\|118498261\|ref\|YP_899311.1\| amidophosphoribosyltransferase [Francisella tularensis subsp. novicida U112] MCGVIGVAGPDQVSYALFYGLSLLQHRGQDAAGIATMDRGHFFIRKNTGLVSDVFTDEKLEKSKGNMGIG HVRYPTAGSLGAADSQPFYVNNPHGIVFAHNGNLTNVPELAQMLHDIERRHLNTSSDSELLLNFFACGMN KSKGSATSEAVYKACKFVFEHVKGGYACTAMIANFGLIAFRDPYGIRPLVLGFKEYDDGEKAYMVASESV ALDISGFKVLRDVEPGEVIIITEDRKVHSKICAKNPVLAPCLFEYVYFARPDSIMNGVSVYQARVDAGKI LSKRIKEAWKDKDIDIVIPVPETGRASAQEIATALGVEYREGFVKNRYVGRTFIMPENVDRKNFVRRKLN PIPAEFRDKNVLLVDDSIVRGTTSKRIIEMIRDLGAKSVYLASVSPAVRYPNVYGIDMPVKSDLIAHGKT IEEIRQWIGVDGLIYLPLEDLKEIIQKQNPKIREFEDSVFSGNYITGDVDDAYLDALEKHRKELKELEKK YKGFDN
Molecule Role	Virmugen
Molecule Role Annotation	Mice, which had been immunized with at least 6.95×103 cfu of F. tularensis U112 purF::Cm, were protected against the subsequent F. tularensis subspecies novicida challenge (Quarry et al., 2007).
Related Vaccines(s)	Francisella tularensis purF mutant vaccine
References

purF