• Vaccine Name: Listeria monocytogenes actA/plcB mutant vaccine
• Target Pathogen: Listeria monocytogenes
• Target Disease: Listeriosis
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• actA gene engineering:
  • Type: Gene mutation
  • Description: This actA/plcB mutant is from Listeria monocytogenes (Darji et al., 2003).
  • Detailed Gene Information: Click Here.
• plcB gene engineering:
  • Type: Gene mutation
  • Description: This actA/plcB mutant is from Listeria monocytogenes (Darji et al., 2003).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intravenous injection (i.v.)

Mouse Response

• Persistence: An actA/plcB mutant is attenuated in mice (Darji et al., 2003).
• Efficacy: An actA/plcB mutant induces significant protection in mice from challenge with wild type L. monocytogenes (Darji et al., 2003).
• Host Ifng (Interferon gamma) response
  • Description: The ΔactAΔplcB mutant is able to induce sufficient IFN-γ in mice to prevent a Th1 to Th2 switch and retains its ability to induce a strong CD8+-mediated T cell response, even though the amount of IFN-gamma produced is less than that produced after infection with the wild type strain (Darji et al., 2003).
  • Detailed Gene Information: Click Here.